Mutagenicity of Carbadox and Several Quinoxaline 1,4-Dioxide Derivatives

Tomoe Negishi; Kazumi Tanaka; Hikoya Hayatsu

doi:10.1248/cpb.28.1347

Mutagenicity of Carbadox and Several Quinoxaline 1,4-Dioxide Derivatives

Tomoe Negishi, Kazumi Tanaka, Hikoya Hayatsu

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Carbadox (2-formylquinoxaline 1,4-dioxide carbomethoxyhydrazone), a feed additive for swine, showed mutagenicity against Salmonella typhimurium TA 98 and TA 100 both in the absence and presence of S-9 mix. The mutagenic activity was stronger than that of quinoxaline 1,4-dioxide and was close to that of benzo[a]pyrene.

Original language	English
Pages (from-to)	1347-1349
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	28
Issue number	4
DOIs	https://doi.org/10.1248/cpb.28.1347
Publication status	Published - Jan 1 1980

Keywords

Ames test
S-9 mix
Salmonella typhimurium
carbadox
mutagenicity
near-UV light
quinoxaline 1,4-dioxide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.28.1347

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title = "Mutagenicity of Carbadox and Several Quinoxaline 1,4-Dioxide Derivatives",

abstract = "Carbadox (2-formylquinoxaline 1,4-dioxide carbomethoxyhydrazone), a feed additive for swine, showed mutagenicity against Salmonella typhimurium TA 98 and TA 100 both in the absence and presence of S-9 mix. The mutagenic activity was stronger than that of quinoxaline 1,4-dioxide and was close to that of benzo[a]pyrene.",

keywords = "Ames test, S-9 mix, Salmonella typhimurium, carbadox, mutagenicity, near-UV light, quinoxaline 1,4-dioxide",

author = "Tomoe Negishi and Kazumi Tanaka and Hikoya Hayatsu",

year = "1980",

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AU - Negishi, Tomoe

AU - Tanaka, Kazumi

AU - Hayatsu, Hikoya

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Y1 - 1980/1/1

N2 - Carbadox (2-formylquinoxaline 1,4-dioxide carbomethoxyhydrazone), a feed additive for swine, showed mutagenicity against Salmonella typhimurium TA 98 and TA 100 both in the absence and presence of S-9 mix. The mutagenic activity was stronger than that of quinoxaline 1,4-dioxide and was close to that of benzo[a]pyrene.

AB - Carbadox (2-formylquinoxaline 1,4-dioxide carbomethoxyhydrazone), a feed additive for swine, showed mutagenicity against Salmonella typhimurium TA 98 and TA 100 both in the absence and presence of S-9 mix. The mutagenic activity was stronger than that of quinoxaline 1,4-dioxide and was close to that of benzo[a]pyrene.

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KW - S-9 mix

KW - Salmonella typhimurium

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KW - mutagenicity

KW - near-UV light

KW - quinoxaline 1,4-dioxide

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