Mutagenicity of Carbadox and Several Quinoxaline 1,4-Dioxide Derivatives

Tomoe Negishi, Kazumi Tanaka, Hikoya Hayatsu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Carbadox (2-formylquinoxaline 1,4-dioxide carbomethoxyhydrazone), a feed additive for swine, showed mutagenicity against Salmonella typhimurium TA 98 and TA 100 both in the absence and presence of S-9 mix. The mutagenic activity was stronger than that of quinoxaline 1,4-dioxide and was close to that of benzo[a]pyrene.

Original languageEnglish
Pages (from-to)1347-1349
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume28
Issue number4
DOIs
Publication statusPublished - Jan 1 1980

Keywords

  • Ames test
  • S-9 mix
  • Salmonella typhimurium
  • carbadox
  • mutagenicity
  • near-UV light
  • quinoxaline 1,4-dioxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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