Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change

Atsunori Kamiya, Toru Kawada, Kenta Yamamoto, Daisaku Michikami, Hideto Ariumi, Tadayoshi Miyamoto, Kazunori Uemura, Masaru Sugimachi, Kenji Sunagawa

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background - Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. Method and Results - In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 μg/kg) followed by phenylephrine (3 μg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition). Conclusions - Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.

Original languageEnglish
Pages (from-to)384-386
Number of pages3
JournalCirculation
Volume112
Issue number3
DOIs
Publication statusPublished - Jul 19 2005
Externally publishedYes

Fingerprint

Pressoreceptors
Kidney
Pressure
Muscles
Baroreflex
Rabbits
Carotid Sinus
Tibial Nerve
Nitroprusside
Phenylephrine
Intravenous Injections
Aorta
Arterial Pressure

Keywords

  • Catecholamines
  • Muscles
  • Nervous system, autonomic
  • Nervous system, sympathetic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change. / Kamiya, Atsunori; Kawada, Toru; Yamamoto, Kenta; Michikami, Daisaku; Ariumi, Hideto; Miyamoto, Tadayoshi; Uemura, Kazunori; Sugimachi, Masaru; Sunagawa, Kenji.

In: Circulation, Vol. 112, No. 3, 19.07.2005, p. 384-386.

Research output: Contribution to journalArticle

Kamiya, Atsunori ; Kawada, Toru ; Yamamoto, Kenta ; Michikami, Daisaku ; Ariumi, Hideto ; Miyamoto, Tadayoshi ; Uemura, Kazunori ; Sugimachi, Masaru ; Sunagawa, Kenji. / Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change. In: Circulation. 2005 ; Vol. 112, No. 3. pp. 384-386.
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AU - Kamiya, Atsunori

AU - Kawada, Toru

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AU - Michikami, Daisaku

AU - Ariumi, Hideto

AU - Miyamoto, Tadayoshi

AU - Uemura, Kazunori

AU - Sugimachi, Masaru

AU - Sunagawa, Kenji

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N2 - Background - Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. Method and Results - In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 μg/kg) followed by phenylephrine (3 μg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition). Conclusions - Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.

AB - Background - Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. Method and Results - In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 μg/kg) followed by phenylephrine (3 μg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition). Conclusions - Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.

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