Abstract
Background - Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. Method and Results - In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 μg/kg) followed by phenylephrine (3 μg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition). Conclusions - Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.
| Original language | English |
|---|---|
| Pages (from-to) | 384-386 |
| Number of pages | 3 |
| Journal | Circulation |
| Volume | 112 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 19 2005 |
| Externally published | Yes |
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Keywords
- Catecholamines
- Muscles
- Nervous system, autonomic
- Nervous system, sympathetic
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
Cite this
Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change. / Kamiya, Atsunori; Kawada, Toru; Yamamoto, Kenta; Michikami, Daisaku; Ariumi, Hideto; Miyamoto, Tadayoshi; Uemura, Kazunori; Sugimachi, Masaru; Sunagawa, Kenji.
In: Circulation, Vol. 112, No. 3, 19.07.2005, p. 384-386.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Muscle sympathetic nerve activity averaged over 1 minute parallels renal and cardiac sympathetic nerve activity in response to a forced baroreceptor pressure change
AU - Kamiya, Atsunori
AU - Kawada, Toru
AU - Yamamoto, Kenta
AU - Michikami, Daisaku
AU - Ariumi, Hideto
AU - Miyamoto, Tadayoshi
AU - Uemura, Kazunori
AU - Sugimachi, Masaru
AU - Sunagawa, Kenji
PY - 2005/7/19
Y1 - 2005/7/19
N2 - Background - Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. Method and Results - In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 μg/kg) followed by phenylephrine (3 μg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition). Conclusions - Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.
AB - Background - Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown. Method and Results - In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 μg/kg) followed by phenylephrine (3 μg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition). Conclusions - Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.
KW - Catecholamines
KW - Muscles
KW - Nervous system, autonomic
KW - Nervous system, sympathetic
UR - http://www.scopus.com/inward/record.url?scp=22544453639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22544453639&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.104.493338
DO - 10.1161/CIRCULATIONAHA.104.493338
M3 - Article
C2 - 15998668
AN - SCOPUS:22544453639
VL - 112
SP - 384
EP - 386
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 3
ER -