Multitracer screening for in vivo element-element interrelations part II

Uptake of 65Zn, 46Sc, 58Co, 54Mn, 75Se, 83Rb, 85Sr and 88Zr by brain and other organs of mice bred under Zn-deficient, -adequate and -excessive diets

Y. Yabushita, Y. Kanayama, T. Tarohda, S. Enomoto, R. Amano

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1 Citation (Scopus)

Abstract

Radioactive multitracer technique was applied to study the screening of in vivo interrelations between radioactive tracers (46Sc, 54Mn, 58Co, 65Zn, 75Se, 83Rb, 85Sr and 88Zr) and stable Zn species. Comparative uptake rates were examined in the blood, nine organs (thymus, lung, cardiac muscle, spleen, pancreas, kidney, liver, testes and bone) and eight brain regions (cerebral cortex, striatum, hippocampus, thalamus and hypothalamus, midbrain, cerebellum, pons and medulla, olfactory bulb) using 3-week-old mice fed by four kinds of Zn-deficient, -adequate and -excessive diets with Zn content from 0.7 to 3520 ppm. As a result, no significant difference between the dietary Zn-deficient state (Zn content: 3.6 ppm) and Zn- adequate state (Zn content: 36 ppm) was observed in the uptake rates of 65Zn and other 46Sc, 54Mn, 58Co and 75Se, except for 83Rb. In addition, significant differences among the organ and brain regional uptakes of 46Sc, 54Mn, 58Co, 75Se and 83Rb were found in the dietary Zn-excessive state (Zn content: 3520 ppm). These results indicate that the organ and brain regional uptakes of tracers in Zn-deficient and excessive mice are strongly correlated with the blood uptakes and retentions of the tracers. Furthermore, the multitracer screening gives us new findings concerning the diet-related element-element interrelations in living bodies.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume256
Issue number3
DOIs
Publication statusPublished - Jun 1 2003
Externally publishedYes

Fingerprint

Nutrition
Brain
Screening
Diet
Blood
Radioactive Tracers
Thymus
Radioactive tracers
Pons
Olfactory Bulb
Mesencephalon
Thalamus
Liver
Cerebral Cortex
Cerebellum
Thymus Gland
Hypothalamus
Muscle
Testis
Pancreas

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

Cite this

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title = "Multitracer screening for in vivo element-element interrelations part II: Uptake of 65Zn, 46Sc, 58Co, 54Mn, 75Se, 83Rb, 85Sr and 88Zr by brain and other organs of mice bred under Zn-deficient, -adequate and -excessive diets",
abstract = "Radioactive multitracer technique was applied to study the screening of in vivo interrelations between radioactive tracers (46Sc, 54Mn, 58Co, 65Zn, 75Se, 83Rb, 85Sr and 88Zr) and stable Zn species. Comparative uptake rates were examined in the blood, nine organs (thymus, lung, cardiac muscle, spleen, pancreas, kidney, liver, testes and bone) and eight brain regions (cerebral cortex, striatum, hippocampus, thalamus and hypothalamus, midbrain, cerebellum, pons and medulla, olfactory bulb) using 3-week-old mice fed by four kinds of Zn-deficient, -adequate and -excessive diets with Zn content from 0.7 to 3520 ppm. As a result, no significant difference between the dietary Zn-deficient state (Zn content: 3.6 ppm) and Zn- adequate state (Zn content: 36 ppm) was observed in the uptake rates of 65Zn and other 46Sc, 54Mn, 58Co and 75Se, except for 83Rb. In addition, significant differences among the organ and brain regional uptakes of 46Sc, 54Mn, 58Co, 75Se and 83Rb were found in the dietary Zn-excessive state (Zn content: 3520 ppm). These results indicate that the organ and brain regional uptakes of tracers in Zn-deficient and excessive mice are strongly correlated with the blood uptakes and retentions of the tracers. Furthermore, the multitracer screening gives us new findings concerning the diet-related element-element interrelations in living bodies.",
author = "Y. Yabushita and Y. Kanayama and T. Tarohda and S. Enomoto and R. Amano",
year = "2003",
month = "6",
day = "1",
doi = "10.1023/A:1024599616035",
language = "English",
volume = "256",
pages = "481--488",
journal = "Journal of Radioanalytical Chemistry",
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TY - JOUR

T1 - Multitracer screening for in vivo element-element interrelations part II

T2 - Uptake of 65Zn, 46Sc, 58Co, 54Mn, 75Se, 83Rb, 85Sr and 88Zr by brain and other organs of mice bred under Zn-deficient, -adequate and -excessive diets

AU - Yabushita, Y.

AU - Kanayama, Y.

AU - Tarohda, T.

AU - Enomoto, S.

AU - Amano, R.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Radioactive multitracer technique was applied to study the screening of in vivo interrelations between radioactive tracers (46Sc, 54Mn, 58Co, 65Zn, 75Se, 83Rb, 85Sr and 88Zr) and stable Zn species. Comparative uptake rates were examined in the blood, nine organs (thymus, lung, cardiac muscle, spleen, pancreas, kidney, liver, testes and bone) and eight brain regions (cerebral cortex, striatum, hippocampus, thalamus and hypothalamus, midbrain, cerebellum, pons and medulla, olfactory bulb) using 3-week-old mice fed by four kinds of Zn-deficient, -adequate and -excessive diets with Zn content from 0.7 to 3520 ppm. As a result, no significant difference between the dietary Zn-deficient state (Zn content: 3.6 ppm) and Zn- adequate state (Zn content: 36 ppm) was observed in the uptake rates of 65Zn and other 46Sc, 54Mn, 58Co and 75Se, except for 83Rb. In addition, significant differences among the organ and brain regional uptakes of 46Sc, 54Mn, 58Co, 75Se and 83Rb were found in the dietary Zn-excessive state (Zn content: 3520 ppm). These results indicate that the organ and brain regional uptakes of tracers in Zn-deficient and excessive mice are strongly correlated with the blood uptakes and retentions of the tracers. Furthermore, the multitracer screening gives us new findings concerning the diet-related element-element interrelations in living bodies.

AB - Radioactive multitracer technique was applied to study the screening of in vivo interrelations between radioactive tracers (46Sc, 54Mn, 58Co, 65Zn, 75Se, 83Rb, 85Sr and 88Zr) and stable Zn species. Comparative uptake rates were examined in the blood, nine organs (thymus, lung, cardiac muscle, spleen, pancreas, kidney, liver, testes and bone) and eight brain regions (cerebral cortex, striatum, hippocampus, thalamus and hypothalamus, midbrain, cerebellum, pons and medulla, olfactory bulb) using 3-week-old mice fed by four kinds of Zn-deficient, -adequate and -excessive diets with Zn content from 0.7 to 3520 ppm. As a result, no significant difference between the dietary Zn-deficient state (Zn content: 3.6 ppm) and Zn- adequate state (Zn content: 36 ppm) was observed in the uptake rates of 65Zn and other 46Sc, 54Mn, 58Co and 75Se, except for 83Rb. In addition, significant differences among the organ and brain regional uptakes of 46Sc, 54Mn, 58Co, 75Se and 83Rb were found in the dietary Zn-excessive state (Zn content: 3520 ppm). These results indicate that the organ and brain regional uptakes of tracers in Zn-deficient and excessive mice are strongly correlated with the blood uptakes and retentions of the tracers. Furthermore, the multitracer screening gives us new findings concerning the diet-related element-element interrelations in living bodies.

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