Multitracer screening for in vivo element-element interrelations: Part I: Uptake of 54Mn, 46Sc, 59Fe, 58Co, 65Zn, 75Se, 83Rb, 85Sr and 88Zr by brain and other organs of mice bred under Mn-deficient, -adequate and -excessive diets

Y. Yabushita, Y. Kanayama, T. Tarohda, R. Amano, S. Enomoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Radioactive multitracer technique was applied to study the screening of in vivo interrelations between radioactive tracers (46Sc, 59Fe, 58Co, 65Zn, 75Se, 83Rb, 85Sr and 88Zr) and stable Mn species. Comparative uptake rates were examined in the blood, 9 organs (thymus, lung, cardiac muscle, spleen, pancreas, kidney, liver, testes and bone) and 8 brain regions (cerebral cortex, striatum, hippocampus, thalamus and hypothalamus, midbrain, cerebellum, pons and medulla, olfactory bulb) using the 3-weeks-old mice fed the Mn-deficient, -adequate or -excessive diets with Mn concentration from 0.4 to 300.4 ppm. Significant diet-related differences were found for 65Zn uptake in some organs. The dietary Mn-deficient state induced increase Zn absorption in thymus and lung in short-time span (during 48 hours after injection). On the other hand, no significant diet-related differences were observed in any brain regional uptake rates except for 54Mn uptake rate. The screening results are expected to give us new findings concerning the diet-related element-element interrelations in living bodies.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume253
Issue number1
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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