Multitracer screening: Brain delivery of trace elements by eight different administration methods

Yousuke Kanayama, Takae Tsuji, Shuichi Enomoto, Ryohei Amano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC), intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements. A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods. This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences in brain uptake pathways among administration methods.

Original languageEnglish
Pages (from-to)553-565
Number of pages13
JournalBioMetals
Volume18
Issue number6
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Fingerprint

Trace Elements
Trace elements
trace elements
Brain
Screening
screening
brain
Intranasal Administration
uptake mechanisms
Cutaneous Administration
intranasal administration
blood circulation
methodology
Blood Circulation
Hemodynamics
radionuclides
Radioisotopes

Keywords

  • Brain delivery
  • Multitracer
  • Trace element

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Multitracer screening : Brain delivery of trace elements by eight different administration methods. / Kanayama, Yousuke; Tsuji, Takae; Enomoto, Shuichi; Amano, Ryohei.

In: BioMetals, Vol. 18, No. 6, 12.2005, p. 553-565.

Research output: Contribution to journalArticle

Kanayama, Yousuke ; Tsuji, Takae ; Enomoto, Shuichi ; Amano, Ryohei. / Multitracer screening : Brain delivery of trace elements by eight different administration methods. In: BioMetals. 2005 ; Vol. 18, No. 6. pp. 553-565.
@article{79c3dd52cdcc49aea2ea3d08ed5ea693,
title = "Multitracer screening: Brain delivery of trace elements by eight different administration methods",
abstract = "Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC), intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements. A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods. This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences in brain uptake pathways among administration methods.",
keywords = "Brain delivery, Multitracer, Trace element",
author = "Yousuke Kanayama and Takae Tsuji and Shuichi Enomoto and Ryohei Amano",
year = "2005",
month = "12",
doi = "10.1007/s10534-005-4775-6",
language = "English",
volume = "18",
pages = "553--565",
journal = "BioMetals",
issn = "0966-0844",
publisher = "Springer Netherlands",
number = "6",

}

TY - JOUR

T1 - Multitracer screening

T2 - Brain delivery of trace elements by eight different administration methods

AU - Kanayama, Yousuke

AU - Tsuji, Takae

AU - Enomoto, Shuichi

AU - Amano, Ryohei

PY - 2005/12

Y1 - 2005/12

N2 - Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC), intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements. A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods. This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences in brain uptake pathways among administration methods.

AB - Trace elements are closely associated with the normal functioning of the brain. Therefore, it is important to determine how trace elements enter, accumulate, and are retained in the brain. Using the multitracer technique, which allows simultaneous tracing of many elements and comparison of their behavior under identical experimental conditions, we examined the influence of different administration methods, i.e., intravenous (IV), intraperitoneal (IP), intramuscular (IM), subcutaneous (SC), intracutaneous (IC), intranasal (IN), peroral (PO), and percutaneous (PC) administration, on the uptake of trace elements. A multitracer solution containing 16 radionuclides (i.e., 7Be, 46Sc, 48V, 51Cr, 54Mn, 59Fe, 56Co, 65Zn, 74As, 75Se, 83Rb, 85Sr, 88Y, 88Zr, 95mTc, and 103Ru) was used. The results indicated that the 83Rb brain uptake rate with intranasal administration was approximately twice those obtained with the other administration methods. This result indicated that a portion of Rb was delivered into the brain circumventing the blood circulation and that delivery could be accomplished mainly by olfactory transport. Multitracer screening of trace element delivery revealed differences in brain uptake pathways among administration methods.

KW - Brain delivery

KW - Multitracer

KW - Trace element

UR - http://www.scopus.com/inward/record.url?scp=29744458583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29744458583&partnerID=8YFLogxK

U2 - 10.1007/s10534-005-4775-6

DO - 10.1007/s10534-005-4775-6

M3 - Article

C2 - 16388395

AN - SCOPUS:29744458583

VL - 18

SP - 553

EP - 565

JO - BioMetals

JF - BioMetals

SN - 0966-0844

IS - 6

ER -