Multiple small tumor formation on both surfaces of the aortic valve cusps in Epstein–Barr virus-associated T/NK-cell lymphoproliferative disease: a case report

Ryuta Tai, Hiroyuki Irie, Yusuke Kinugasa, Hideki Teshima, Masahiko Ikebuchi, Keiko Kaneko, Nobuhiro Miyazaki, Hideaki Enzan, Tadashi Yoshino

Research output: Contribution to journalArticlepeer-review

Abstract

A 41-year-old woman presented acute cerebral infarction. Transesophageal echocardiography revealed multiple masses only on both surfaces of the aortic valve cusps. There was no primary lesion outside the heart according to various examinations. After treatment for cerebral infarction, we replaced the aortic valve instead of preservation because the intraoperative histological examination reported that malignancy was highly suspected. Contrary to the rapid frozen section diagnosis, histological and immunohistochemical examinations failed to exhibit malignancy. The tumors were composed of atypical large lymphoid cells and they were assessed to be related to T-/natural killer-cells. Furthermore, Epstein–Barr virus related markers were also positive. Her three-year postoperative course was uneventful without chemotherapy. We report an extremely rare case of Epstein–Barr virus-associated T-/natural killer-cell lymphoproliferative disease which formed multiple small tumors on both surfaces of the aortic valve.

Original languageEnglish
JournalGeneral Thoracic and Cardiovascular Surgery
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Aortic valve
  • Cardiac tumor
  • Epstein–Barr virus
  • Lymphoproliferative disease

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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