Multiple receptors underlie glutamate taste responses in mice

Keiko Yasumatsu, Nao Horio, Yoshihiro Murata, Shinya Shirosaki, Tadahiro Ohkuri, Ryusuke Yoshida, Yuzo Ninomiya

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

L-Glutamate is known to elicit a unique taste, umami, that is distinct from the tastes of sweet, salty, sour, and bitter. Recent molecular studies have identified several candidate receptors for umami in taste cells, such as the heterodimer T1R1/T1R3 and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain-mGluR1, brain-mGluR4, taste-mGluR1, and taste-mGluR4). However, the relative contributions of these receptors to umami taste reception remain to be elucidated. We critically discuss data from recent studies in which mouse taste cell, nerve fiber, and behavioral responses to umami stimuli were measured to evaluate whether receptors other than T1R1/T1R3 are involved in umami responses. We particularly emphasized studies of umami responses in T1R3 knockout (KO) mice and studies of potential effects of mGluR antagonists on taste responses. The results of these studies indicate the existence of substantial residual responses to umami compounds in the T1R3-KO model and a significant reduction of umami responsiveness after administration of mGluR antagonists. These findings thus provide evidence of the involvement of mGluRs in addition to T1R1/T1R3 in umami detection in mice and suggest that umami responses, at least in mice, may be mediated by multiple receptors.

Original languageEnglish
Pages (from-to)747S-752S
JournalAmerican Journal of Clinical Nutrition
Volume90
Issue number3
DOIs
Publication statusPublished - Sep 1 2009
Externally publishedYes

Fingerprint

Glutamate Receptors
Brain
Nerve Fibers
Knockout Mice
Glutamic Acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Yasumatsu, K., Horio, N., Murata, Y., Shirosaki, S., Ohkuri, T., Yoshida, R., & Ninomiya, Y. (2009). Multiple receptors underlie glutamate taste responses in mice. American Journal of Clinical Nutrition, 90(3), 747S-752S. https://doi.org/10.3945/ajcn.2009.27462J

Multiple receptors underlie glutamate taste responses in mice. / Yasumatsu, Keiko; Horio, Nao; Murata, Yoshihiro; Shirosaki, Shinya; Ohkuri, Tadahiro; Yoshida, Ryusuke; Ninomiya, Yuzo.

In: American Journal of Clinical Nutrition, Vol. 90, No. 3, 01.09.2009, p. 747S-752S.

Research output: Contribution to journalArticle

Yasumatsu, K, Horio, N, Murata, Y, Shirosaki, S, Ohkuri, T, Yoshida, R & Ninomiya, Y 2009, 'Multiple receptors underlie glutamate taste responses in mice', American Journal of Clinical Nutrition, vol. 90, no. 3, pp. 747S-752S. https://doi.org/10.3945/ajcn.2009.27462J
Yasumatsu, Keiko ; Horio, Nao ; Murata, Yoshihiro ; Shirosaki, Shinya ; Ohkuri, Tadahiro ; Yoshida, Ryusuke ; Ninomiya, Yuzo. / Multiple receptors underlie glutamate taste responses in mice. In: American Journal of Clinical Nutrition. 2009 ; Vol. 90, No. 3. pp. 747S-752S.
@article{a47b4c93e1214bad87878abb4fc54ae2,
title = "Multiple receptors underlie glutamate taste responses in mice",
abstract = "L-Glutamate is known to elicit a unique taste, umami, that is distinct from the tastes of sweet, salty, sour, and bitter. Recent molecular studies have identified several candidate receptors for umami in taste cells, such as the heterodimer T1R1/T1R3 and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain-mGluR1, brain-mGluR4, taste-mGluR1, and taste-mGluR4). However, the relative contributions of these receptors to umami taste reception remain to be elucidated. We critically discuss data from recent studies in which mouse taste cell, nerve fiber, and behavioral responses to umami stimuli were measured to evaluate whether receptors other than T1R1/T1R3 are involved in umami responses. We particularly emphasized studies of umami responses in T1R3 knockout (KO) mice and studies of potential effects of mGluR antagonists on taste responses. The results of these studies indicate the existence of substantial residual responses to umami compounds in the T1R3-KO model and a significant reduction of umami responsiveness after administration of mGluR antagonists. These findings thus provide evidence of the involvement of mGluRs in addition to T1R1/T1R3 in umami detection in mice and suggest that umami responses, at least in mice, may be mediated by multiple receptors.",
author = "Keiko Yasumatsu and Nao Horio and Yoshihiro Murata and Shinya Shirosaki and Tadahiro Ohkuri and Ryusuke Yoshida and Yuzo Ninomiya",
year = "2009",
month = "9",
day = "1",
doi = "10.3945/ajcn.2009.27462J",
language = "English",
volume = "90",
pages = "747S--752S",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Multiple receptors underlie glutamate taste responses in mice

AU - Yasumatsu, Keiko

AU - Horio, Nao

AU - Murata, Yoshihiro

AU - Shirosaki, Shinya

AU - Ohkuri, Tadahiro

AU - Yoshida, Ryusuke

AU - Ninomiya, Yuzo

PY - 2009/9/1

Y1 - 2009/9/1

N2 - L-Glutamate is known to elicit a unique taste, umami, that is distinct from the tastes of sweet, salty, sour, and bitter. Recent molecular studies have identified several candidate receptors for umami in taste cells, such as the heterodimer T1R1/T1R3 and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain-mGluR1, brain-mGluR4, taste-mGluR1, and taste-mGluR4). However, the relative contributions of these receptors to umami taste reception remain to be elucidated. We critically discuss data from recent studies in which mouse taste cell, nerve fiber, and behavioral responses to umami stimuli were measured to evaluate whether receptors other than T1R1/T1R3 are involved in umami responses. We particularly emphasized studies of umami responses in T1R3 knockout (KO) mice and studies of potential effects of mGluR antagonists on taste responses. The results of these studies indicate the existence of substantial residual responses to umami compounds in the T1R3-KO model and a significant reduction of umami responsiveness after administration of mGluR antagonists. These findings thus provide evidence of the involvement of mGluRs in addition to T1R1/T1R3 in umami detection in mice and suggest that umami responses, at least in mice, may be mediated by multiple receptors.

AB - L-Glutamate is known to elicit a unique taste, umami, that is distinct from the tastes of sweet, salty, sour, and bitter. Recent molecular studies have identified several candidate receptors for umami in taste cells, such as the heterodimer T1R1/T1R3 and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain-mGluR1, brain-mGluR4, taste-mGluR1, and taste-mGluR4). However, the relative contributions of these receptors to umami taste reception remain to be elucidated. We critically discuss data from recent studies in which mouse taste cell, nerve fiber, and behavioral responses to umami stimuli were measured to evaluate whether receptors other than T1R1/T1R3 are involved in umami responses. We particularly emphasized studies of umami responses in T1R3 knockout (KO) mice and studies of potential effects of mGluR antagonists on taste responses. The results of these studies indicate the existence of substantial residual responses to umami compounds in the T1R3-KO model and a significant reduction of umami responsiveness after administration of mGluR antagonists. These findings thus provide evidence of the involvement of mGluRs in addition to T1R1/T1R3 in umami detection in mice and suggest that umami responses, at least in mice, may be mediated by multiple receptors.

UR - http://www.scopus.com/inward/record.url?scp=70349577145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349577145&partnerID=8YFLogxK

U2 - 10.3945/ajcn.2009.27462J

DO - 10.3945/ajcn.2009.27462J

M3 - Article

C2 - 19571210

AN - SCOPUS:70349577145

VL - 90

SP - 747S-752S

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -