Multiple primary malignancies in patients with non-small cell lung cancer

Shiro Fujita, Katsuhiro Masago, Jumpei Takeshita, Yosuke Togashi, Akito Hata, Reiko Kaji, Masaki Kokubo, Nobuyuki Katakami

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Objective Information regarding multiple primary malignancies is important, as it has the potential to clarify etiological factors and may indicate the need to refine patient follow-up to include screening for associated malignancies. Upper aerodigestive tract cancer often develops in patients with smoking-related lung cancer; however, little is known about the frequencies or types of other primary malignancies in patients with non-small cell lung cancer (NSCLC) without a history of smoking. Methods We retrospectively evaluated the records of patients examined and/or treated for NSCLC at the Institute of Biomedical Research and Innovation between January 2007 and June 2012. Patients In total, 938 patients, including 599 men (never-smoker/ever-smoker: 35/564) and 339 women (never-smoker/ever-smoker: 236/103), were analyzed. Results Among the 209 patients (22.3%) with multiple primary malignancies, 151 had a history of smoking and 58 were never-smokers. The most common cancers were gastric (43 cases), colorectal (33 cases), and prostate (29 cases) cancer. Smoking-related cancer was more common in current smokers and ex-smokers for both men and women. Among women with NSCLC, never-smokers were more likely to have thyroid cancer than those with a history of smoking (5.1% vs. 0%, p=0.021). Conclusion In this study, several differences in malignancies were observed between never-smokers and patients with a history of smoking. Thyroid cancer and NSCLC co-existed in some women without a history of smoking, implicating predisposing factors other than tobacco smoke in the onset of these cancers.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalInternal Medicine
Volume54
Issue number3
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Multiple primary malignancies
  • Non-small cell lung cancer
  • Smoking
  • Thyroid cancer

ASJC Scopus subject areas

  • Internal Medicine

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