Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle

Shin Sukegawa, Takeshi Miyake, Takayuki Ibi, Yoichi Takahagi, Hiroshi Murakami, Fumiki Morimatsu, Takahisa Yamada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Marbling in beef, measured by Beef Marbling Standard (BMS) number, is an economically important trait for beef cattle breeding and markets in Japan. We previously detected three single nucleotide polymorphisms (SNPs) associated with BMS number of Japanese Black in Oita prefecture: c.*188G>A in AKIRIN2, g.1471620G>T in EDG1 and g.3109537C>T in RPL27A. Here, we carried out single and multiple marker association analyses for the three SNPs in a different commercial Japanese Black population of 892 genotyped animals. The single marker analyses with the model including a single SNP showed significant associations of all SNPs with BMS number. The multiple marker analysis with the model including the main effects of the three SNPs and their interactions detected only significant main effects of g.1471620G>T and g.3109537C>T and a significant interaction between c.*188G>A and g.1471620G>T. These findings suggest the presence of inter-allelic interactions among genes affecting the development of beef marbling. For effective marker-assisted selection for BMS number, interactions among these markers need to be considered.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalAnimal Science Journal
Volume85
Issue number3
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Wagyu
marbling
single nucleotide polymorphism
Single Nucleotide Polymorphism
beef
cattle
Genes
genes
cattle breeding
gene interaction
marker-assisted selection
beef cattle
Breeding
Red Meat
Japan
markets
Population
animals

Keywords

  • Association
  • Beef cattle
  • Interaction
  • Marbling
  • SNP

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Medicine(all)

Cite this

Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle. / Sukegawa, Shin; Miyake, Takeshi; Ibi, Takayuki; Takahagi, Yoichi; Murakami, Hiroshi; Morimatsu, Fumiki; Yamada, Takahisa.

In: Animal Science Journal, Vol. 85, No. 3, 03.2014, p. 193-197.

Research output: Contribution to journalArticle

Sukegawa, Shin ; Miyake, Takeshi ; Ibi, Takayuki ; Takahagi, Yoichi ; Murakami, Hiroshi ; Morimatsu, Fumiki ; Yamada, Takahisa. / Multiple marker effects of single nucleotide polymorphisms in three genes, AKIRIN2, EDG1 and RPL27A, for marbling development in Japanese Black cattle. In: Animal Science Journal. 2014 ; Vol. 85, No. 3. pp. 193-197.
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