Abstract
Objective: One of the clinically significant adverse effects of olanzapine treatment is weight gain, which shows substantial inter-individual differences and may be influenced by genetic variation. The aim of this investigation was identification of genetic risk factors associated with olanzapine-induced weight gain. Method: Inpatients with DSM-IV-TR schizophrenia (N = 164) were administered olanzapine for 8 to 24 (mean ± SD = 17.9 ± 9.4) weeks. The clinical background, body mass index (BMI), and clinical response to olanzapine were investigated. Twenty-one loci of diverse candidate genes encoding dopamine, serotonin (5-HT), histamine, and adrenergic receptors, tumor necrosis factor-alpha, ghrelin, adiponectin, and peroxisome proliferator- activated receptor gamma-2, were analyzed. The study was conducted from June 2001 to June 2003 at 4 psychiatric hospitals in Japan. Results: BMI increased by a mean ± SD 4.3 ± 10.7% after treatment with olanzapine (mean ± SD dose = 15.5 ± 5.8 mg/day). Olanzapine-induced weight gain correlated negatively with baseline BMI and positively with clinical global improvement and the length of olanzapine treatment (p <.0001), but it did not correlate with the daily dose of olanzapine, concomitant antipsychotics, sex, age, or smoking. Four genetic variants, the 102T allele of HTR2A, the 825T allele of GNB3, the 23Cys allele of HTR2C, and the 64Arg/Arg genotype of ADRB3, were significantly associated with olanzapine-induced weight gain. Stepwise regression analysis revealed that the baseline BMI predicted 12.5% of the weight gain, and the 2 latter genetic factors added 6.8%. The patients with double and triple genetic risk factors showed 5.1% and 8.8% BMI increases, respectively, during olanzapine treatment, whereas the patients with a single or no risk factor showed approximately a 1% BMI increase. Conclusions: We identified genetic variants of 5-HT2A and 5-HT2C receptors, the G-protein beta-3 subunit, and the adrenergic receptor beta-3, as genetic risk factors for olanzapine-induced weight gain, and they showed additive genetic effects on weight gain.
| Original language | English |
|---|---|
| Pages (from-to) | 1416-1422 |
| Number of pages | 7 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 69 |
| Issue number | 9 |
| Publication status | Published - Sep 2008 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
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Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients : A cohort study. / Ujike, Hiroshi; Nomura, Akira; Morita, Yukitaka; Morio, Akiko; Okahisa, Yuko; Kotaka, Tatsuya; Kodama, Masafumi; Ishihara, Takeshi; Kuroda, Shigetoshi.
In: Journal of Clinical Psychiatry, Vol. 69, No. 9, 09.2008, p. 1416-1422.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients
T2 - A cohort study
AU - Ujike, Hiroshi
AU - Nomura, Akira
AU - Morita, Yukitaka
AU - Morio, Akiko
AU - Okahisa, Yuko
AU - Kotaka, Tatsuya
AU - Kodama, Masafumi
AU - Ishihara, Takeshi
AU - Kuroda, Shigetoshi
PY - 2008/9
Y1 - 2008/9
N2 - Objective: One of the clinically significant adverse effects of olanzapine treatment is weight gain, which shows substantial inter-individual differences and may be influenced by genetic variation. The aim of this investigation was identification of genetic risk factors associated with olanzapine-induced weight gain. Method: Inpatients with DSM-IV-TR schizophrenia (N = 164) were administered olanzapine for 8 to 24 (mean ± SD = 17.9 ± 9.4) weeks. The clinical background, body mass index (BMI), and clinical response to olanzapine were investigated. Twenty-one loci of diverse candidate genes encoding dopamine, serotonin (5-HT), histamine, and adrenergic receptors, tumor necrosis factor-alpha, ghrelin, adiponectin, and peroxisome proliferator- activated receptor gamma-2, were analyzed. The study was conducted from June 2001 to June 2003 at 4 psychiatric hospitals in Japan. Results: BMI increased by a mean ± SD 4.3 ± 10.7% after treatment with olanzapine (mean ± SD dose = 15.5 ± 5.8 mg/day). Olanzapine-induced weight gain correlated negatively with baseline BMI and positively with clinical global improvement and the length of olanzapine treatment (p <.0001), but it did not correlate with the daily dose of olanzapine, concomitant antipsychotics, sex, age, or smoking. Four genetic variants, the 102T allele of HTR2A, the 825T allele of GNB3, the 23Cys allele of HTR2C, and the 64Arg/Arg genotype of ADRB3, were significantly associated with olanzapine-induced weight gain. Stepwise regression analysis revealed that the baseline BMI predicted 12.5% of the weight gain, and the 2 latter genetic factors added 6.8%. The patients with double and triple genetic risk factors showed 5.1% and 8.8% BMI increases, respectively, during olanzapine treatment, whereas the patients with a single or no risk factor showed approximately a 1% BMI increase. Conclusions: We identified genetic variants of 5-HT2A and 5-HT2C receptors, the G-protein beta-3 subunit, and the adrenergic receptor beta-3, as genetic risk factors for olanzapine-induced weight gain, and they showed additive genetic effects on weight gain.
AB - Objective: One of the clinically significant adverse effects of olanzapine treatment is weight gain, which shows substantial inter-individual differences and may be influenced by genetic variation. The aim of this investigation was identification of genetic risk factors associated with olanzapine-induced weight gain. Method: Inpatients with DSM-IV-TR schizophrenia (N = 164) were administered olanzapine for 8 to 24 (mean ± SD = 17.9 ± 9.4) weeks. The clinical background, body mass index (BMI), and clinical response to olanzapine were investigated. Twenty-one loci of diverse candidate genes encoding dopamine, serotonin (5-HT), histamine, and adrenergic receptors, tumor necrosis factor-alpha, ghrelin, adiponectin, and peroxisome proliferator- activated receptor gamma-2, were analyzed. The study was conducted from June 2001 to June 2003 at 4 psychiatric hospitals in Japan. Results: BMI increased by a mean ± SD 4.3 ± 10.7% after treatment with olanzapine (mean ± SD dose = 15.5 ± 5.8 mg/day). Olanzapine-induced weight gain correlated negatively with baseline BMI and positively with clinical global improvement and the length of olanzapine treatment (p <.0001), but it did not correlate with the daily dose of olanzapine, concomitant antipsychotics, sex, age, or smoking. Four genetic variants, the 102T allele of HTR2A, the 825T allele of GNB3, the 23Cys allele of HTR2C, and the 64Arg/Arg genotype of ADRB3, were significantly associated with olanzapine-induced weight gain. Stepwise regression analysis revealed that the baseline BMI predicted 12.5% of the weight gain, and the 2 latter genetic factors added 6.8%. The patients with double and triple genetic risk factors showed 5.1% and 8.8% BMI increases, respectively, during olanzapine treatment, whereas the patients with a single or no risk factor showed approximately a 1% BMI increase. Conclusions: We identified genetic variants of 5-HT2A and 5-HT2C receptors, the G-protein beta-3 subunit, and the adrenergic receptor beta-3, as genetic risk factors for olanzapine-induced weight gain, and they showed additive genetic effects on weight gain.
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UR - http://www.scopus.com/inward/citedby.url?scp=52649105994&partnerID=8YFLogxK
M3 - Article
C2 - 19193342
AN - SCOPUS:52649105994
VL - 69
SP - 1416
EP - 1422
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
SN - 0160-6689
IS - 9
ER -