Multiple expression of glucose transporters in the lateral wall of the cochlear duct studied by quantitative real-time PCR assay

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Abstract

We have investigated the gene expression of the facilitated glucose transporter (GLUT), H+-coupled myo-inositol cotransporter (HMIT), and Na+ glucose cotransporter (SGLT) in the lateral wall of the cochlear duct by conventional RT-PCR and quantitative real-time PCR. The isoforms GLUT1, -3, -4, -5, -8, -10, -12 and HMIT were detected in both the stria vascularis and the spiral ligament, whereas no SGLT isoforms could be detected in these tissues. Quantitative real-time PCR analysis revealed significant differences in the gene expression of GLUT1, -4, -5, -10, and HMIT isoforms between the stria vascularis and the spiral ligament. This result reflects the tissue-dependent distributions of GLUT isoforms. These findings strongly suggest that a number of GLUT isoforms participate in glucose transport in the stria vascularis and the spiral ligament.

Original languageEnglish
Pages (from-to)72-77
Number of pages6
JournalNeuroscience Letters
Volume490
Issue number1
DOIs
Publication statusPublished - Feb 18 2011

Keywords

  • GLUT
  • Inner ear
  • SLC2A
  • Spiral ligament
  • Stria vascularis

ASJC Scopus subject areas

  • Neuroscience(all)

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