Abstract
To clarify the diagnostic value of the dipole localization method in estimating the epileptic focus in various types of localization-related epilepsy, dipole analysis of interictal spikes in epileptic patients was performed. Three-layered realistically-shaped models (Scalp-Skull-Brain model, SSB model) were used to compare the results with regional abnormalities revealed by various neuroimaging techniques and clinical manifestations. Subjects were 22 patients with localization-related epilepsy, including 11 cases with localized MRI abnormalities and 9 cases with abnormal SPECT findings. The results of spike dipole location coincided with the clinical findings in 20 of 22 cases. In the two cases with frontal lobe epilepsy, the results did not coincide. In 10 of 11 cases with MRI abnormality dipoles were located within the area of organic lesions. In all 10 cases with SPECT abnormal findings, regional hypoperfusion was found at the area corresponding to the location of the dipole, although SPECT findings showed a wider area as the epileptic focus. In conclusion, dipole estimation using the SSB model can be considered to be a useful technique for noninvasive investigation of epileptic focus.
| Original language | English |
|---|---|
| Pages (from-to) | 51-58 |
| Number of pages | 8 |
| Journal | Brain Topography |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1996 |
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Keywords
- Dipole analysis
- Epilepsy
- Mesial temporal sclerosis
- MR-spectroscopy
- Single-photon emission computed tomography
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Multimodal estimation of epileptic foci with dipole localization method and other technique. / Yoshinaga, Harumi; Sato, Masahiro; Sanada, Satoshi; Asano, Takashi; Nakahori, Tomoyuki; Oka, Eiji; Ohtahara, Shunsuke.
In: Brain Topography, Vol. 9, No. 1, 1996, p. 51-58.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multimodal estimation of epileptic foci with dipole localization method and other technique
AU - Yoshinaga, Harumi
AU - Sato, Masahiro
AU - Sanada, Satoshi
AU - Asano, Takashi
AU - Nakahori, Tomoyuki
AU - Oka, Eiji
AU - Ohtahara, Shunsuke
PY - 1996
Y1 - 1996
N2 - To clarify the diagnostic value of the dipole localization method in estimating the epileptic focus in various types of localization-related epilepsy, dipole analysis of interictal spikes in epileptic patients was performed. Three-layered realistically-shaped models (Scalp-Skull-Brain model, SSB model) were used to compare the results with regional abnormalities revealed by various neuroimaging techniques and clinical manifestations. Subjects were 22 patients with localization-related epilepsy, including 11 cases with localized MRI abnormalities and 9 cases with abnormal SPECT findings. The results of spike dipole location coincided with the clinical findings in 20 of 22 cases. In the two cases with frontal lobe epilepsy, the results did not coincide. In 10 of 11 cases with MRI abnormality dipoles were located within the area of organic lesions. In all 10 cases with SPECT abnormal findings, regional hypoperfusion was found at the area corresponding to the location of the dipole, although SPECT findings showed a wider area as the epileptic focus. In conclusion, dipole estimation using the SSB model can be considered to be a useful technique for noninvasive investigation of epileptic focus.
AB - To clarify the diagnostic value of the dipole localization method in estimating the epileptic focus in various types of localization-related epilepsy, dipole analysis of interictal spikes in epileptic patients was performed. Three-layered realistically-shaped models (Scalp-Skull-Brain model, SSB model) were used to compare the results with regional abnormalities revealed by various neuroimaging techniques and clinical manifestations. Subjects were 22 patients with localization-related epilepsy, including 11 cases with localized MRI abnormalities and 9 cases with abnormal SPECT findings. The results of spike dipole location coincided with the clinical findings in 20 of 22 cases. In the two cases with frontal lobe epilepsy, the results did not coincide. In 10 of 11 cases with MRI abnormality dipoles were located within the area of organic lesions. In all 10 cases with SPECT abnormal findings, regional hypoperfusion was found at the area corresponding to the location of the dipole, although SPECT findings showed a wider area as the epileptic focus. In conclusion, dipole estimation using the SSB model can be considered to be a useful technique for noninvasive investigation of epileptic focus.
KW - Dipole analysis
KW - Epilepsy
KW - Mesial temporal sclerosis
KW - MR-spectroscopy
KW - Single-photon emission computed tomography
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UR - http://www.scopus.com/inward/citedby.url?scp=0029834947&partnerID=8YFLogxK
U2 - 10.1007/BF01191642
DO - 10.1007/BF01191642
M3 - Article
AN - SCOPUS:0029834947
VL - 9
SP - 51
EP - 58
JO - Brain Topography
JF - Brain Topography
SN - 0896-0267
IS - 1
ER -