Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8

Nobuharu Fujii, Kazuma Ikeda, Naoto Takahashi, Kensuke Kojima, Yoshimi Kobayashi, Atsuko Ashiba, Katsuto Takenaka, Shunnichi Fukuda, Katsuji Shinagawa, Fumihiko Ishimaru, Kenji Niiya, Ikuo Miura, Mitsune Tanimoto, Mine Harada

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalBritish Journal of Haematology
Volume119
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Myeloid Sarcoma
Hypereosinophilic Syndrome
Eosinophils
Neutrophils
Myeloproliferative Disorders
Erythroblasts
Fluorescence In Situ Hybridization
Karyotype
Acute Myeloid Leukemia
Bone Marrow Cells
Cerebrospinal Fluid
Chromosomes
Observation
Staining and Labeling
Brain
Trisomy Chromosome 8
May-Grunwald Giemsa

Keywords

  • Chronic eosinophilic leukaemia
  • Granulocytic sarcoma
  • Hypereosinophilic syndrome
  • Leukaemic transformation
  • Trisomy 8

ASJC Scopus subject areas

  • Hematology

Cite this

Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8. / Fujii, Nobuharu; Ikeda, Kazuma; Takahashi, Naoto; Kojima, Kensuke; Kobayashi, Yoshimi; Ashiba, Atsuko; Takenaka, Katsuto; Fukuda, Shunnichi; Shinagawa, Katsuji; Ishimaru, Fumihiko; Niiya, Kenji; Miura, Ikuo; Tanimoto, Mitsune; Harada, Mine.

In: British Journal of Haematology, Vol. 119, No. 3, 2002, p. 716-719.

Research output: Contribution to journalArticle

Fujii, N, Ikeda, K, Takahashi, N, Kojima, K, Kobayashi, Y, Ashiba, A, Takenaka, K, Fukuda, S, Shinagawa, K, Ishimaru, F, Niiya, K, Miura, I, Tanimoto, M & Harada, M 2002, 'Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8', British Journal of Haematology, vol. 119, no. 3, pp. 716-719. https://doi.org/10.1046/j.1365-2141.2002.03922.x
Fujii, Nobuharu ; Ikeda, Kazuma ; Takahashi, Naoto ; Kojima, Kensuke ; Kobayashi, Yoshimi ; Ashiba, Atsuko ; Takenaka, Katsuto ; Fukuda, Shunnichi ; Shinagawa, Katsuji ; Ishimaru, Fumihiko ; Niiya, Kenji ; Miura, Ikuo ; Tanimoto, Mitsune ; Harada, Mine. / Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8. In: British Journal of Haematology. 2002 ; Vol. 119, No. 3. pp. 716-719.
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AU - Ashiba, Atsuko

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AB - We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.

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