Multigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives

Tomohiro Takaishi, Kyosuke Wakisaka, Christopher J. Vavricka, Hiromasa Kiyota, Minoru Izumi

Research output: Contribution to journalArticle

Abstract

Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.

Original languageEnglish
Pages (from-to)2126-2134
Number of pages9
JournalHeterocycles
Volume96
Issue number12
DOIs
Publication statusPublished - Jan 1 2018

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Azetidinecarboxylic Acid
Column chromatography
Silica Gel
Aspartic Acid
Purification
Gel Chromatography
Chromatography
Fluorescence
Derivatives
nicotianamine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

Multigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives. / Takaishi, Tomohiro; Wakisaka, Kyosuke; Vavricka, Christopher J.; Kiyota, Hiromasa; Izumi, Minoru.

In: Heterocycles, Vol. 96, No. 12, 01.01.2018, p. 2126-2134.

Research output: Contribution to journalArticle

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