Abstract
Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.
| Original language | English |
|---|---|
| Pages (from-to) | 2126-2134 |
| Number of pages | 9 |
| Journal | Heterocycles |
| Volume | 96 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
Cite this
Multigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives. / Takaishi, Tomohiro; Wakisaka, Kyosuke; Vavricka, Christopher J.; Kiyota, Hiromasa; Izumi, Minoru.
In: Heterocycles, Vol. 96, No. 12, 01.01.2018, p. 2126-2134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives
AU - Takaishi, Tomohiro
AU - Wakisaka, Kyosuke
AU - Vavricka, Christopher J.
AU - Kiyota, Hiromasa
AU - Izumi, Minoru
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.
AB - Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.
UR - http://www.scopus.com/inward/record.url?scp=85063682699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063682699&partnerID=8YFLogxK
U2 - 10.3987/COM-18-14002
DO - 10.3987/COM-18-14002
M3 - Article
VL - 96
SP - 2126
EP - 2134
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
IS - 12
ER -