Abstract
Multigram-scale synthesis of L-azetidine-2-carboxylic acid from L-aspartic acid was achieved in 13 conventional synthetic steps, without the need for purification by silica-gel column chromatography and expensive reagents. Nicotianamine and its fluorescence-labeled derivatives could be obtained from this synthetic strategy.
| Original language | English |
|---|---|
| Pages (from-to) | 2126-2134 |
| Number of pages | 9 |
| Journal | Heterocycles |
| Volume | 96 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
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Cite this
Takaishi, T., Wakisaka, K., Vavricka, C. J., Kiyota, H., & Izumi, M. (2018). Multigram-scale and column chromatography-free synthesis of L-azetidine-2-carboxylic acid for the synthesis of nicotianamine and its derivatives. Heterocycles, 96(12), 2126-2134. https://doi.org/10.3987/COM-18-14002