Multifunctional cytotoxic agents from Anacardium occidentale

Isao Kubo; Teruhiko Nitoda; Felismino E. Tocoli; Ivan R. Green

doi:10.1002/ptr.3109

Multifunctional cytotoxic agents from Anacardium occidentale

Isao Kubo, Teruhiko Nitoda, Felismino E. Tocoli, Ivan R. Green

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.

Original language	English
Pages (from-to)	38-45
Number of pages	8
Journal	Phytotherapy Research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1002/ptr.3109
Publication status	Published - Jan 1 2011
Externally published	Yes

Keywords

Anacardium occidentale
B16-F10 melanoma cell
anacardic acids
cardols
tyrosinase

ASJC Scopus subject areas

Pharmacology

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10.1002/ptr.3109

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abstract = "The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.",

keywords = "Anacardium occidentale, B16-F10 melanoma cell, anacardic acids, cardols, tyrosinase",

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AB - The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.

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KW - cardols

KW - tyrosinase

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Multifunctional cytotoxic agents from Anacardium occidentale

Abstract

Keywords

ASJC Scopus subject areas

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