Multifunctional cytotoxic agents from Anacardium occidentale

Isao Kubo, Teruhiko Nitoda, Felismino E. Tocoli, Ivan R. Green

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalPhytotherapy Research
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Fingerprint

Anacardic Acids
Anacardium
Cytotoxins
Anacardiaceae
Experimental Melanomas
Nuts
Monophenol Monooxygenase
Melanocytes
Melanins
Malus
Cultured Cells
Enzymes
adipostatin A

Keywords

  • anacardic acids
  • Anacardium occidentale
  • B16-F10 melanoma cell
  • cardols
  • tyrosinase

ASJC Scopus subject areas

  • Pharmacology

Cite this

Multifunctional cytotoxic agents from Anacardium occidentale. / Kubo, Isao; Nitoda, Teruhiko; Tocoli, Felismino E.; Green, Ivan R.

In: Phytotherapy Research, Vol. 25, No. 1, 01.2011, p. 38-45.

Research output: Contribution to journalArticle

Kubo, Isao ; Nitoda, Teruhiko ; Tocoli, Felismino E. ; Green, Ivan R. / Multifunctional cytotoxic agents from Anacardium occidentale. In: Phytotherapy Research. 2011 ; Vol. 25, No. 1. pp. 38-45.
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