Abstract
The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 38-45 |
| Number of pages | 8 |
| Journal | Phytotherapy Research |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2011 |
| Externally published | Yes |
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Keywords
- anacardic acids
- Anacardium occidentale
- B16-F10 melanoma cell
- cardols
- tyrosinase
ASJC Scopus subject areas
- Pharmacology
Cite this
Multifunctional cytotoxic agents from Anacardium occidentale. / Kubo, Isao; Nitoda, Teruhiko; Tocoli, Felismino E.; Green, Ivan R.
In: Phytotherapy Research, Vol. 25, No. 1, 01.2011, p. 38-45.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multifunctional cytotoxic agents from Anacardium occidentale
AU - Kubo, Isao
AU - Nitoda, Teruhiko
AU - Tocoli, Felismino E.
AU - Green, Ivan R.
PY - 2011/1
Y1 - 2011/1
N2 - The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
AB - The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
KW - anacardic acids
KW - Anacardium occidentale
KW - B16-F10 melanoma cell
KW - cardols
KW - tyrosinase
UR - http://www.scopus.com/inward/record.url?scp=78650673531&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650673531&partnerID=8YFLogxK
U2 - 10.1002/ptr.3109
DO - 10.1002/ptr.3109
M3 - Article
C2 - 20623613
AN - SCOPUS:78650673531
VL - 25
SP - 38
EP - 45
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 1
ER -