Abstract
The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 38-45 |
| Number of pages | 8 |
| Journal | Phytotherapy Research |
| Volume | 25 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2011 |
| Externally published | Yes |
Keywords
- Anacardium occidentale
- B16-F10 melanoma cell
- anacardic acids
- cardols
- tyrosinase
ASJC Scopus subject areas
- Pharmacology
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Cite this
Kubo, I., Nitoda, T., Tocoli, F. E., & Green, I. R. (2011). Multifunctional cytotoxic agents from Anacardium occidentale. Phytotherapy Research, 25(1), 38-45. https://doi.org/10.1002/ptr.3109