Multifunctional cytotoxic agents from Anacardium occidentale

Isao Kubo, Teruhiko Nitoda, Felismino E. Tocoli, Ivan R. Green

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The effects of anacardic acids and cardols isolated from the cashew nut and apple Anacardium occidentale (Anacardiaceae) on murine B16-F10 melanoma cells were tested. Although anacardic acids and cardols were found to inhibit tyrosinase, a key enzyme in melanin synthesis, melanogenesis in melanocytes was not suppressed in cultured cells but rather enhanced. Both anacardic acids and cardols exhibited moderate cytotoxicity.

Original languageEnglish
Pages (from-to)38-45
Number of pages8
JournalPhytotherapy Research
Issue number1
Publication statusPublished - Jan 1 2011
Externally publishedYes


  • Anacardium occidentale
  • B16-F10 melanoma cell
  • anacardic acids
  • cardols
  • tyrosinase

ASJC Scopus subject areas

  • Pharmacology


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