Multifunctional bone morphogenetic protein system in endocrinology

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushing's disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.

Original languageEnglish
Pages (from-to)75-86
Number of pages12
JournalActa Medica Okayama
Volume67
Issue number2
Publication statusPublished - 2013

Fingerprint

Endocrinology
Bone Morphogenetic Proteins
Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 15
Bone Morphogenetic Protein 6
Luteinization
Prolactinoma
Pituitary ACTH Hypersecretion
Endocrine System
Ovarian Follicle
Pituitary Neoplasms
Adrenal Glands
Bioactivity
Aldosterone
Osteogenesis
Catecholamines
Oocytes
Reproduction
Tumors
Ovary

Keywords

  • Bone morphogenetic protein
  • Folliculogenesis
  • Pituitary adenoma
  • Steroidogenesis
  • Transforming growth factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Multifunctional bone morphogenetic protein system in endocrinology. / Otsuka, Fumio.

In: Acta Medica Okayama, Vol. 67, No. 2, 2013, p. 75-86.

Research output: Contribution to journalArticle

@article{5db61efcb3c74433bcfc6d0cc2402f36,
title = "Multifunctional bone morphogenetic protein system in endocrinology",
abstract = "New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushing's disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.",
keywords = "Bone morphogenetic protein, Folliculogenesis, Pituitary adenoma, Steroidogenesis, Transforming growth factor",
author = "Fumio Otsuka",
year = "2013",
language = "English",
volume = "67",
pages = "75--86",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "2",

}

TY - JOUR

T1 - Multifunctional bone morphogenetic protein system in endocrinology

AU - Otsuka, Fumio

PY - 2013

Y1 - 2013

N2 - New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushing's disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.

AB - New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushing's disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.

KW - Bone morphogenetic protein

KW - Folliculogenesis

KW - Pituitary adenoma

KW - Steroidogenesis

KW - Transforming growth factor

UR - http://www.scopus.com/inward/record.url?scp=84878645737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878645737&partnerID=8YFLogxK

M3 - Article

VL - 67

SP - 75

EP - 86

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 2

ER -