Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma

Takeo Fujita, Hiroyoshi Doihara, Daisuke Takabatake, Hirotoshi Takahashi, Seiji Yoshitomi, Yoichi Ishibe, Yutaka Ogasawara, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Several reports supported the association of higher ipsilateral breast tumor recurrence rates with positive or intermediate margins compared with negative pathologic margins. Precise evaluation of intraductal component and adequate surgical margin are important factors affecting the tumor recurrence after breast conserving surgery. Numerous studies have reported the utility of magnetic resonance imaging for diagnosing developing intraductal extension of breast cancer, but few have investigated multidetector-row computed tomography (MD-CT). The present study evaluated the clinical utility of MD-CT for detecting intraductal extension of breast carcinoma, and analyzed clinical parameters affecting the detection of intraductal extension under MD-CT. Methods: Subjects comprised 44 patients grouped into three categories according to degree of intraductal extension of the main tumor under MD-CT (Intraductal spread grade 1∼3: IDS 1∼3). Tumors were also categorized histopathologically (p-IDS 0∼3), and CT-pathological correlations were examined retrospectively. Clinical parameters were evaluated to determine the affect on detection of intraductal components. Results: MD-CT detected 44 breast lesions (100%). Sensitivity for detection of intraductal component was 81.2%, specificity was 67.8%, and accuracy was 72.7%. Regarding extent of intraductal components, significant correlations were found between histopathological and MD-CT findings. A strong correlation was found in postmenopausal women between T2 tumor and high histological grade. Conclusions: MD-CT findings of intraductal extension from breast carcinoma correlate with histological degree of intraductal extension, and MD-CT may be useful for preoperative assessment of breast-conserving surgery, particularly for postmenopausal women with histological high nuclear grade and T2 tumor.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalJournal of Surgical Oncology
Volume91
Issue number1
DOIs
Publication statusPublished - Jul 1 2005

Fingerprint

Multidetector Computed Tomography
Breast Neoplasms
Segmental Mastectomy
Neoplasms
Recurrence
Breast
Magnetic Resonance Imaging

Keywords

  • Breast cancer
  • Breast-conserving surgery
  • Histological grade
  • Intraductal extension
  • Menopausal status
  • Multidetector-row computed tomography
  • Tumor size

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Fujita, T., Doihara, H., Takabatake, D., Takahashi, H., Yoshitomi, S., Ishibe, Y., ... Shimizu, N. (2005). Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma. Journal of Surgical Oncology, 91(1), 10-16. https://doi.org/10.1002/jso.20275

Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma. / Fujita, Takeo; Doihara, Hiroyoshi; Takabatake, Daisuke; Takahashi, Hirotoshi; Yoshitomi, Seiji; Ishibe, Yoichi; Ogasawara, Yutaka; Shimizu, Nobuyoshi.

In: Journal of Surgical Oncology, Vol. 91, No. 1, 01.07.2005, p. 10-16.

Research output: Contribution to journalArticle

Fujita, T, Doihara, H, Takabatake, D, Takahashi, H, Yoshitomi, S, Ishibe, Y, Ogasawara, Y & Shimizu, N 2005, 'Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma', Journal of Surgical Oncology, vol. 91, no. 1, pp. 10-16. https://doi.org/10.1002/jso.20275
Fujita, Takeo ; Doihara, Hiroyoshi ; Takabatake, Daisuke ; Takahashi, Hirotoshi ; Yoshitomi, Seiji ; Ishibe, Yoichi ; Ogasawara, Yutaka ; Shimizu, Nobuyoshi. / Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma. In: Journal of Surgical Oncology. 2005 ; Vol. 91, No. 1. pp. 10-16.
@article{ace0802f3ea743bc8f8b52a8780bf9d2,
title = "Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma",
abstract = "Objectives: Several reports supported the association of higher ipsilateral breast tumor recurrence rates with positive or intermediate margins compared with negative pathologic margins. Precise evaluation of intraductal component and adequate surgical margin are important factors affecting the tumor recurrence after breast conserving surgery. Numerous studies have reported the utility of magnetic resonance imaging for diagnosing developing intraductal extension of breast cancer, but few have investigated multidetector-row computed tomography (MD-CT). The present study evaluated the clinical utility of MD-CT for detecting intraductal extension of breast carcinoma, and analyzed clinical parameters affecting the detection of intraductal extension under MD-CT. Methods: Subjects comprised 44 patients grouped into three categories according to degree of intraductal extension of the main tumor under MD-CT (Intraductal spread grade 1∼3: IDS 1∼3). Tumors were also categorized histopathologically (p-IDS 0∼3), and CT-pathological correlations were examined retrospectively. Clinical parameters were evaluated to determine the affect on detection of intraductal components. Results: MD-CT detected 44 breast lesions (100{\%}). Sensitivity for detection of intraductal component was 81.2{\%}, specificity was 67.8{\%}, and accuracy was 72.7{\%}. Regarding extent of intraductal components, significant correlations were found between histopathological and MD-CT findings. A strong correlation was found in postmenopausal women between T2 tumor and high histological grade. Conclusions: MD-CT findings of intraductal extension from breast carcinoma correlate with histological degree of intraductal extension, and MD-CT may be useful for preoperative assessment of breast-conserving surgery, particularly for postmenopausal women with histological high nuclear grade and T2 tumor.",
keywords = "Breast cancer, Breast-conserving surgery, Histological grade, Intraductal extension, Menopausal status, Multidetector-row computed tomography, Tumor size",
author = "Takeo Fujita and Hiroyoshi Doihara and Daisuke Takabatake and Hirotoshi Takahashi and Seiji Yoshitomi and Yoichi Ishibe and Yutaka Ogasawara and Nobuyoshi Shimizu",
year = "2005",
month = "7",
day = "1",
doi = "10.1002/jso.20275",
language = "English",
volume = "91",
pages = "10--16",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Multidetector row computed tomography for diagnosing intraductal extension of breast carcinoma

AU - Fujita, Takeo

AU - Doihara, Hiroyoshi

AU - Takabatake, Daisuke

AU - Takahashi, Hirotoshi

AU - Yoshitomi, Seiji

AU - Ishibe, Yoichi

AU - Ogasawara, Yutaka

AU - Shimizu, Nobuyoshi

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Objectives: Several reports supported the association of higher ipsilateral breast tumor recurrence rates with positive or intermediate margins compared with negative pathologic margins. Precise evaluation of intraductal component and adequate surgical margin are important factors affecting the tumor recurrence after breast conserving surgery. Numerous studies have reported the utility of magnetic resonance imaging for diagnosing developing intraductal extension of breast cancer, but few have investigated multidetector-row computed tomography (MD-CT). The present study evaluated the clinical utility of MD-CT for detecting intraductal extension of breast carcinoma, and analyzed clinical parameters affecting the detection of intraductal extension under MD-CT. Methods: Subjects comprised 44 patients grouped into three categories according to degree of intraductal extension of the main tumor under MD-CT (Intraductal spread grade 1∼3: IDS 1∼3). Tumors were also categorized histopathologically (p-IDS 0∼3), and CT-pathological correlations were examined retrospectively. Clinical parameters were evaluated to determine the affect on detection of intraductal components. Results: MD-CT detected 44 breast lesions (100%). Sensitivity for detection of intraductal component was 81.2%, specificity was 67.8%, and accuracy was 72.7%. Regarding extent of intraductal components, significant correlations were found between histopathological and MD-CT findings. A strong correlation was found in postmenopausal women between T2 tumor and high histological grade. Conclusions: MD-CT findings of intraductal extension from breast carcinoma correlate with histological degree of intraductal extension, and MD-CT may be useful for preoperative assessment of breast-conserving surgery, particularly for postmenopausal women with histological high nuclear grade and T2 tumor.

AB - Objectives: Several reports supported the association of higher ipsilateral breast tumor recurrence rates with positive or intermediate margins compared with negative pathologic margins. Precise evaluation of intraductal component and adequate surgical margin are important factors affecting the tumor recurrence after breast conserving surgery. Numerous studies have reported the utility of magnetic resonance imaging for diagnosing developing intraductal extension of breast cancer, but few have investigated multidetector-row computed tomography (MD-CT). The present study evaluated the clinical utility of MD-CT for detecting intraductal extension of breast carcinoma, and analyzed clinical parameters affecting the detection of intraductal extension under MD-CT. Methods: Subjects comprised 44 patients grouped into three categories according to degree of intraductal extension of the main tumor under MD-CT (Intraductal spread grade 1∼3: IDS 1∼3). Tumors were also categorized histopathologically (p-IDS 0∼3), and CT-pathological correlations were examined retrospectively. Clinical parameters were evaluated to determine the affect on detection of intraductal components. Results: MD-CT detected 44 breast lesions (100%). Sensitivity for detection of intraductal component was 81.2%, specificity was 67.8%, and accuracy was 72.7%. Regarding extent of intraductal components, significant correlations were found between histopathological and MD-CT findings. A strong correlation was found in postmenopausal women between T2 tumor and high histological grade. Conclusions: MD-CT findings of intraductal extension from breast carcinoma correlate with histological degree of intraductal extension, and MD-CT may be useful for preoperative assessment of breast-conserving surgery, particularly for postmenopausal women with histological high nuclear grade and T2 tumor.

KW - Breast cancer

KW - Breast-conserving surgery

KW - Histological grade

KW - Intraductal extension

KW - Menopausal status

KW - Multidetector-row computed tomography

KW - Tumor size

UR - http://www.scopus.com/inward/record.url?scp=22044442663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22044442663&partnerID=8YFLogxK

U2 - 10.1002/jso.20275

DO - 10.1002/jso.20275

M3 - Article

C2 - 15999347

AN - SCOPUS:22044442663

VL - 91

SP - 10

EP - 16

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 1

ER -