Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer

Nobukazu Fujimoto, Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, Akihiro Bessho, Ichiro Takata, Kazutaka Sunami, Yasushi Hiramatsu, Kazuma Ikeda, Mitsune Tanimoto, Mine Harada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year. After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT. Definite regression of the tumors was observed. Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced. These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.

Original languageEnglish
Pages (from-to)4229-4232
Number of pages4
JournalAnticancer Research
Volume23
Issue number5 B
Publication statusPublished - Sep 2003

Fingerprint

Cell Transplantation
Small Cell Lung Carcinoma
Blood Cells
Stem Cells
Drug Therapy
Etoposide
Ifosfamide
Granulocyte Colony-Stimulating Factor
Neutropenia
Thrombocytopenia
Cisplatin
Thorax
Neoplasms
Therapeutics

Keywords

  • Autologous blood progenitor cell transplantation (ABPCT)
  • Dose-intensive chemotherapy
  • Second-line chemotherapy
  • Small cell lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer. / Fujimoto, Nobukazu; Ueoka, Hiroshi; Kiura, Katsuyuki; Tabata, Masahiro; Bessho, Akihiro; Takata, Ichiro; Sunami, Kazutaka; Hiramatsu, Yasushi; Ikeda, Kazuma; Tanimoto, Mitsune; Harada, Mine.

In: Anticancer Research, Vol. 23, No. 5 B, 09.2003, p. 4229-4232.

Research output: Contribution to journalArticle

Fujimoto, N, Ueoka, H, Kiura, K, Tabata, M, Bessho, A, Takata, I, Sunami, K, Hiramatsu, Y, Ikeda, K, Tanimoto, M & Harada, M 2003, 'Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer', Anticancer Research, vol. 23, no. 5 B, pp. 4229-4232.
Fujimoto, Nobukazu ; Ueoka, Hiroshi ; Kiura, Katsuyuki ; Tabata, Masahiro ; Bessho, Akihiro ; Takata, Ichiro ; Sunami, Kazutaka ; Hiramatsu, Yasushi ; Ikeda, Kazuma ; Tanimoto, Mitsune ; Harada, Mine. / Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer. In: Anticancer Research. 2003 ; Vol. 23, No. 5 B. pp. 4229-4232.
@article{06a355a5785c40c3bd5f32b9a4d5a293,
title = "Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer",
abstract = "We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year. After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT. Definite regression of the tumors was observed. Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced. These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.",
keywords = "Autologous blood progenitor cell transplantation (ABPCT), Dose-intensive chemotherapy, Second-line chemotherapy, Small cell lung cancer",
author = "Nobukazu Fujimoto and Hiroshi Ueoka and Katsuyuki Kiura and Masahiro Tabata and Akihiro Bessho and Ichiro Takata and Kazutaka Sunami and Yasushi Hiramatsu and Kazuma Ikeda and Mitsune Tanimoto and Mine Harada",
year = "2003",
month = "9",
language = "English",
volume = "23",
pages = "4229--4232",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5 B",

}

TY - JOUR

T1 - Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer

AU - Fujimoto, Nobukazu

AU - Ueoka, Hiroshi

AU - Kiura, Katsuyuki

AU - Tabata, Masahiro

AU - Bessho, Akihiro

AU - Takata, Ichiro

AU - Sunami, Kazutaka

AU - Hiramatsu, Yasushi

AU - Ikeda, Kazuma

AU - Tanimoto, Mitsune

AU - Harada, Mine

PY - 2003/9

Y1 - 2003/9

N2 - We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year. After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT. Definite regression of the tumors was observed. Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced. These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.

AB - We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year. After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT. Definite regression of the tumors was observed. Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced. These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.

KW - Autologous blood progenitor cell transplantation (ABPCT)

KW - Dose-intensive chemotherapy

KW - Second-line chemotherapy

KW - Small cell lung cancer

UR - http://www.scopus.com/inward/record.url?scp=0344440879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344440879&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 4229

EP - 4232

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5 B

ER -