Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer

Nobukazu Fujimoto, Hiroshi Ueoka, Katsuyuki Kiura, Masahiro Tabata, Akihiro Bessho, Ichiro Takata, Kazutaka Sunami, Yasushi Hiramatsu, Kazuma Ikeda, Mitsune Tanimoto, Mine Harada

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2 Citations (Scopus)

Abstract

We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year. After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT. Definite regression of the tumors was observed. Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced. These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.

Original languageEnglish
Pages (from-to)4229-4232
Number of pages4
JournalAnticancer research
Volume23
Issue number5 B
Publication statusPublished - Sep 1 2003

Keywords

  • Autologous blood progenitor cell transplantation (ABPCT)
  • Dose-intensive chemotherapy
  • Second-line chemotherapy
  • Small cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Fujimoto, N., Ueoka, H., Kiura, K., Tabata, M., Bessho, A., Takata, I., Sunami, K., Hiramatsu, Y., Ikeda, K., Tanimoto, M., & Harada, M. (2003). Multicyclic Dose-intensive Chemotherapy Supported by Autologous Blood Progenitor Cell Transplantation for Relapsed Small Cell Lung Cancer. Anticancer research, 23(5 B), 4229-4232.