Multicentric Castleman's disease associated with inherited epidermolysis bullosa

Yoshio Kawakami, Akiko Nishibu, Satoshi Kikuchi, Mikio Ohtsuka, Koichiro Nakamura, Yoshihiro Nozawa, Masafumi Abe, Keiji Iwatsuki, Fumio Kaneko

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2 Citations (Scopus)

Abstract

Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalJournal of Dermatology
Volume30
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

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Keywords

  • Dystrophic epidermolysis bullosa
  • Hypergammaglobulinemia
  • Interleukin-6

ASJC Scopus subject areas

  • Dermatology

Cite this

Kawakami, Y., Nishibu, A., Kikuchi, S., Ohtsuka, M., Nakamura, K., Nozawa, Y., Abe, M., Iwatsuki, K., & Kaneko, F. (2003). Multicentric Castleman's disease associated with inherited epidermolysis bullosa. Journal of Dermatology, 30(9), 689-693. https://doi.org/10.1111/j.1346-8138.2003.tb00459.x