Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis

Ken Ichi Kozaki, Katsumi Koshikawa, Yoshio Tatematsu, Osamu Miyaishi, Hiroko Saito, Toyoaki Hida, Hirotaka Osada, Takashi Takahashi

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57 Citations (Scopus)

Abstract

This study established and characterized low-metastatic revertant and parental clones of a highly metastatic human lung cancer cell line, NCI-H460-LNM35 (hereafter referred to as LNM35). Expression-profiling analysis revealed that up-regulation of various proinflammatory cytokines and angiogenic chemotactic chemokines was present in LNM35. Further, while COX-2 itself is known to be inducible in inflammation, COX-2 expression levels correlated well with the capabilities of these clones for not only in vitro motility and invasion but also in vivo metastasis, and COX-2 inhibitors were shown for the first time to reduce lung cancer metastasis in vivo. These findings suggest that lung cancer cells may mimic inflammatory cells in the process of metastasis.

Original languageEnglish
Pages (from-to)4228-4234
Number of pages7
JournalOncogene
Volume20
Issue number31
DOIs
Publication statusPublished - Jul 12 2001

Keywords

  • Expression profiling
  • Human lung cancer
  • Inflammation
  • Invasion
  • Metastasis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Kozaki, K. I., Koshikawa, K., Tatematsu, Y., Miyaishi, O., Saito, H., Hida, T., Osada, H., & Takahashi, T. (2001). Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. Oncogene, 20(31), 4228-4234. https://doi.org/10.1038/sj.onc.1204561