MTOR regulates the nucleoplasmic diffusion of Xrn2 under conditions of heat stress

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5 Citations (Scopus)

Abstract

Stress induces various responses, including translational suppression and tRNA degradation in mammals. Previously, we showed that heat stress induces degradation of initiator tRNAMet (iMet) through 5′-3′ exoribonuclease Xrn1 and Xrn2, respectively. In addition, we found that rapamycin inhibits the degradation of iMet under heat stress conditions. Here, we report that the mammalian target of rapamycin (mTOR) regulates the diffusion of Xrn2 from the nucleolus to the nucleoplasm, facilitating the degradation of iMet under conditions of heat stress. Our results suggest a mechanism of translational suppression through mTOR-regulated iMet degradation in mammalian cells.

Original languageEnglish
Pages (from-to)3454-3460
Number of pages7
JournalFEBS Letters
Volume588
Issue number18
DOIs
Publication statusPublished - Sep 17 2014

Keywords

  • Heat stress
  • Mammalian target of rapamycin
  • Xrn2
  • tRNA degradation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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