MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy

Teppei Matsui, Kenji W. Koyano, Minoru Koyama, Kiyoshi Nakahara, Masaki Takeda, Yohei Ohashi, Yuji Naya, Yasushi Miyashita

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The localization of microelectrode recording sites in the layers of primate cerebral cortex permits the analysis of relationships between recorded neuronal activities and underlying anatomical connections. We present a magnetic resonance imaging method for precise in vivo localization of cortical recording sites. In this method, the susceptibility-induced effect thickens the appearance of the microelectrode and enhances the detectability of the microelectrode tip, which usually occupies less than a few percent of the volume of an image voxel. In a phantom study, the optimized susceptibility-induced effect allowed tip detection with single-voxel accuracy (in-plane resolution, 50 μm). We applied this method to recording microelectrodes inserted into the brains of macaque monkeys, and localized the microelectrode tip at an in-plane resolution of 150 μm within the cortex of 2-3 mm in thickness. Subsequent histological analyses validated the single-voxel accuracy of the in vivo tip localization. This method opens up a way to investigate information flow during cognitive processes in the brain.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalNature Methods
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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