Mouse optical imaging for understanding resting-state functional connectivity in human fMRI

Teppei Matsui, Tomonari Murakami, Kenichi Ohki

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Resting-state functional connectivity (FC), which measures the temporal correlation of spontaneous hemodynamic activity between distant brain areas, is a widely accepted method in functional magnetic resonance imaging (fMRI) to assess the connectome of healthy and diseased human brains. A common assumption underlying FC is that it reflects the temporal structure of large-scale neuronal activity that is converted into large-scale hemodynamic activity. However, direct observation of such relationship has been difficult. In this commentary, we describe our recent progress regarding this topic. Recently, transgenic mice that express a genetically encoded calcium indicator (GCaMP) in neocortical neurons are enabling the optical recording of neuronal activity in large-scale with high spatiotemporal resolution. Using these mice, we devised a method to simultaneously monitor neuronal and hemodynamic activity and addressed some key issues related to the neuronal basis of FC. We propose that many important questions about human resting-state fMRI can be answered using GCaMP expressing transgenic mice as a model system.

Original languageEnglish
Article numbere1528821
JournalCommunicative and Integrative Biology
Issue number4
Publication statusPublished - Jul 4 2018
Externally publishedYes


  • calcium imaging
  • fMRI
  • functional connectivity
  • mouse
  • resting-state

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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