TY - JOUR
T1 - Mouse optical imaging for understanding resting-state functional connectivity in human fMRI
AU - Matsui, Teppei
AU - Murakami, Tomonari
AU - Ohki, Kenichi
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Sciences [17K14931]; Japan Society for the Promotion of Sciences [18H05116]; AMED [Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/ MINDS)]; Japan Society for the Promotion of Sciences [World Premium Institute (WPI)].
Funding Information:
This work was supported by grants from Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/ MINDS)—AMED (to K.O.), Japan Society for the Promotion of Science (JSPS) KAKENHI(Grant number 17K14931 and 18H05116 to T. Matsui and 18H06084 to T. Murakami), World Premium Institute (WPI), JSPS (to K.O.), Strategic International Research Cooperative Program (SICP) —AMED (to K.O.), Asashi Glass Foundation (to T.Matsui).
Publisher Copyright:
© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2018/7/4
Y1 - 2018/7/4
N2 - Resting-state functional connectivity (FC), which measures the temporal correlation of spontaneous hemodynamic activity between distant brain areas, is a widely accepted method in functional magnetic resonance imaging (fMRI) to assess the connectome of healthy and diseased human brains. A common assumption underlying FC is that it reflects the temporal structure of large-scale neuronal activity that is converted into large-scale hemodynamic activity. However, direct observation of such relationship has been difficult. In this commentary, we describe our recent progress regarding this topic. Recently, transgenic mice that express a genetically encoded calcium indicator (GCaMP) in neocortical neurons are enabling the optical recording of neuronal activity in large-scale with high spatiotemporal resolution. Using these mice, we devised a method to simultaneously monitor neuronal and hemodynamic activity and addressed some key issues related to the neuronal basis of FC. We propose that many important questions about human resting-state fMRI can be answered using GCaMP expressing transgenic mice as a model system.
AB - Resting-state functional connectivity (FC), which measures the temporal correlation of spontaneous hemodynamic activity between distant brain areas, is a widely accepted method in functional magnetic resonance imaging (fMRI) to assess the connectome of healthy and diseased human brains. A common assumption underlying FC is that it reflects the temporal structure of large-scale neuronal activity that is converted into large-scale hemodynamic activity. However, direct observation of such relationship has been difficult. In this commentary, we describe our recent progress regarding this topic. Recently, transgenic mice that express a genetically encoded calcium indicator (GCaMP) in neocortical neurons are enabling the optical recording of neuronal activity in large-scale with high spatiotemporal resolution. Using these mice, we devised a method to simultaneously monitor neuronal and hemodynamic activity and addressed some key issues related to the neuronal basis of FC. We propose that many important questions about human resting-state fMRI can be answered using GCaMP expressing transgenic mice as a model system.
KW - calcium imaging
KW - fMRI
KW - functional connectivity
KW - mouse
KW - resting-state
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U2 - 10.1080/19420889.2018.1528821
DO - 10.1080/19420889.2018.1528821
M3 - Review article
AN - SCOPUS:85057042394
VL - 11
JO - Communicative and Integrative Biology
JF - Communicative and Integrative Biology
SN - 1942-0889
IS - 4
M1 - e1528821
ER -