Mouse Model for Optogenetic Genome Engineering

Research output: Contribution to journalReview articlepeer-review

Abstract

Optogenetics, a technology to manipulate biological phenomena thorough light, has attracted much attention in neuroscience. Recently, the Magnet System, a photo-inducible protein dimerization system which can control the intracellular behavior of various biomolecules with high accuracy using light was developed. Furthermore, photoactivation systems for controlling biological phenomena are being developed by combining this technique with genome-editing technology (CRISPR/Cas9 System) or DNA recombination technology (Cre-loxP system). Herein, we review the history of optogenetics and the latest Magnet System technology and introduce our recently developed photoactivatable Cre knock-in mice with temporal-, spatial-, and cell-specific accuracy.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalActa medica Okayama
Volume76
Issue number1
DOIs
Publication statusPublished - 2022

Keywords

  • Cre recombinase
  • Optogenetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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