Mouse hepatic microsomal oxidation of aliphatic aldehydes (C8 to C011) to carboxylic acids

Kazuhito Watanabe, Tamihide Matsunaga, Shizuo Narimatsu, Ikuo Yamamoto, Hiddetoshi Yoshimura

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Addition of saturated and α, β-unsaturated aliphatic aldehydes (C8 to C11) significantly increased NADPH oxidation with mouse hepatic microsomes, and the aldehydes themselves were oxidized to the corresponding carboxylic acids. When these aldehyde substrates were incubated similarly under oxygen-18 gas and the carboxylic acids formed were analyzed by GC-MS after methylation, it was indicated that oxygen-18 was significantly incorporated into the carboxylic acids formed from α,β-unsaturated aldehydes, but not significantly into the carboxylic acids formed from saturated aldehydes. These results indicate that enzyme and/or mechanism responsible for the oxidation of these two types of aldehydes is different from each other.

Original languageEnglish
Pages (from-to)114-119
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume188
Issue number1
DOIs
Publication statusPublished - Oct 15 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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