Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior

Hidenori Sagara, Yoshihisa Kitamura, Satoru Esumi, Toshiaki Sendo, Hiroaki Araki, Yutaka Gomita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It is well known that priming stimulation promotes the motivational effects of intracranial self-stimulation (ICSS) behavior. An experimental methodology using the runway method could separately study the reward and motivational effects of ICSS behavior. In the present study, we examined the motivational effect of nicotine as measured by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) in rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus, and rats were trained to get a reward stimulation (50-200 μA, 0.2 ms, 60 Hz) of MFB when the goal lever was pressed. After the rats were trained to press the lever, a priming stimulation of the MFB was performed. After receiving the priming stimulation, rats were placed at the start box of the runway apparatus, and the running time duration until the goal lever was pressed was measured. Subcutaneous injection of nicotine at a dose of 0.2 mg/kg produced an increase in running speed to obtain the reward stimulation, and priming stimulation facilitated the motivational effect to obtain the electrical brain stimulation reward in the rats. These results suggest that nicotine significantly enhanced the motivational effect on ICSS behavior as determined using the runway method. The runway method using priming stimulation of ICSS behavior may become the new experimental methodology with which to measure the motivational effect of some drugs. Copyright

Original languageEnglish
Article number2
JournalActa Medica Okayama
Volume62
Issue number4
Publication statusPublished - Aug 2008

Fingerprint

Self Stimulation
Medial Forebrain Bundle
Nicotine
Rats
Reward
Running
Implanted Electrodes
Deep Brain Stimulation
Subcutaneous Injections
Brain
Electrodes
Pharmaceutical Preparations

Keywords

  • Intracranial self-stimulation
  • Motivational effect
  • Nicotine
  • Priming stimulation
  • Runway

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior. / Sagara, Hidenori; Kitamura, Yoshihisa; Esumi, Satoru; Sendo, Toshiaki; Araki, Hiroaki; Gomita, Yutaka.

In: Acta Medica Okayama, Vol. 62, No. 4, 2, 08.2008.

Research output: Contribution to journalArticle

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