Abstract
A historical cohort study was conducted in Misasa town, Tottori prefecture, Japan, where radon spas have been operating for a long time. Misasa town was divided into an elevated radon level area and a control area, with mean indoor radon levels of about 60 and 20 Bq/m3, respectively. In total, 3083 subjects in the elevated radon level area and 1248 in the control area, all aged 40 or older on January 1, 1976, were followed up until December 31, 1993, for a mean period of 14 years. The mortality rates from all causes exhibited no difference between the elevated radon level area and the control area for both sexes. No difference was observed in the incidence of all-site cancers (age, period-adjusted rate ratios by Poisson regression, RR = 1.06, 95% confidence interval (CI) 0.79-1.42 for males, RR = 0.90, 95% CI 0.65-1.24 for females), while stomach cancer incidence seemed to decrease for both sexes (RR = 0.70, 95% CI 0.44-1.11 for male, RR = 0.58, 95% CI 0.34-1.00 for female) and lung cancer incidence for males only seemed to increase (RR = 1.65, 95% CI 0.83-3.30 for male, RR = 1.07, 95% CI 0.28-4.14 for female) in the elevated radon level area. Caution is needed in the interpretation of these findings, however, since the individual exposure level was not measured and major confounding factors, such as smoking and diet, could not be controlled in this study.
| Original language | English |
|---|---|
| Pages (from-to) | 789-796 |
| Number of pages | 8 |
| Journal | Japanese Journal of Cancer Research |
| Volume | 89 |
| Issue number | 8 |
| Publication status | Published - Aug 1998 |
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Keywords
- Cancer incidence
- Indoor radon exposure
- Mortality
- Radon spa
- Risk
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Mortality and cancer incidence in Misasa, Japan, a spa area with elevated radon levels. / Ye, Weimin; Sobue, Tomotaka; Lee, Valerie S.; Tanooka, Hiroshi; Mifune, Masaki; Suyama, Akihiko; Koga, Taeko; Morishima, Hiroshige; Kondo, Sohei.
In: Japanese Journal of Cancer Research, Vol. 89, No. 8, 08.1998, p. 789-796.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mortality and cancer incidence in Misasa, Japan, a spa area with elevated radon levels
AU - Ye, Weimin
AU - Sobue, Tomotaka
AU - Lee, Valerie S.
AU - Tanooka, Hiroshi
AU - Mifune, Masaki
AU - Suyama, Akihiko
AU - Koga, Taeko
AU - Morishima, Hiroshige
AU - Kondo, Sohei
PY - 1998/8
Y1 - 1998/8
N2 - A historical cohort study was conducted in Misasa town, Tottori prefecture, Japan, where radon spas have been operating for a long time. Misasa town was divided into an elevated radon level area and a control area, with mean indoor radon levels of about 60 and 20 Bq/m3, respectively. In total, 3083 subjects in the elevated radon level area and 1248 in the control area, all aged 40 or older on January 1, 1976, were followed up until December 31, 1993, for a mean period of 14 years. The mortality rates from all causes exhibited no difference between the elevated radon level area and the control area for both sexes. No difference was observed in the incidence of all-site cancers (age, period-adjusted rate ratios by Poisson regression, RR = 1.06, 95% confidence interval (CI) 0.79-1.42 for males, RR = 0.90, 95% CI 0.65-1.24 for females), while stomach cancer incidence seemed to decrease for both sexes (RR = 0.70, 95% CI 0.44-1.11 for male, RR = 0.58, 95% CI 0.34-1.00 for female) and lung cancer incidence for males only seemed to increase (RR = 1.65, 95% CI 0.83-3.30 for male, RR = 1.07, 95% CI 0.28-4.14 for female) in the elevated radon level area. Caution is needed in the interpretation of these findings, however, since the individual exposure level was not measured and major confounding factors, such as smoking and diet, could not be controlled in this study.
AB - A historical cohort study was conducted in Misasa town, Tottori prefecture, Japan, where radon spas have been operating for a long time. Misasa town was divided into an elevated radon level area and a control area, with mean indoor radon levels of about 60 and 20 Bq/m3, respectively. In total, 3083 subjects in the elevated radon level area and 1248 in the control area, all aged 40 or older on January 1, 1976, were followed up until December 31, 1993, for a mean period of 14 years. The mortality rates from all causes exhibited no difference between the elevated radon level area and the control area for both sexes. No difference was observed in the incidence of all-site cancers (age, period-adjusted rate ratios by Poisson regression, RR = 1.06, 95% confidence interval (CI) 0.79-1.42 for males, RR = 0.90, 95% CI 0.65-1.24 for females), while stomach cancer incidence seemed to decrease for both sexes (RR = 0.70, 95% CI 0.44-1.11 for male, RR = 0.58, 95% CI 0.34-1.00 for female) and lung cancer incidence for males only seemed to increase (RR = 1.65, 95% CI 0.83-3.30 for male, RR = 1.07, 95% CI 0.28-4.14 for female) in the elevated radon level area. Caution is needed in the interpretation of these findings, however, since the individual exposure level was not measured and major confounding factors, such as smoking and diet, could not be controlled in this study.
KW - Cancer incidence
KW - Indoor radon exposure
KW - Mortality
KW - Radon spa
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=0031693629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031693629&partnerID=8YFLogxK
M3 - Article
C2 - 9765613
AN - SCOPUS:0031693629
VL - 89
SP - 789
EP - 796
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 8
ER -