Morphine-induced changes in histamine dynamics in mouse brain

Masahiro Nishibori, R. Oishi, Y. Itoh, K. Saeki

Research output: Contribution to journalArticle

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Abstract

The effect of the acute morphine treatment on histamine (HA) pools in the brain and the spinal cord was examined in mice. Morphine (1-50 mg/kg, s.c.) administered alone caused no significant change in the steady-state levels of HA and its major metabolite, tele-methylhistamine (t-MH), in the brain. However, depending on the doses tested, morphine significantly enhanced the pargyline (65 mg/kg, i.p.)-induced accumulation of t-MH and this effect was antagonized by naloxone. A specific inhibitor of histidine decarboxylase, α-fluoromethylhistidine (α-FMH) (50 mg/kg i.p.), decreased the brain HA level in consequence of the almost complete depletion of the HA pool with a rapid turnover. Morphine further decreased the brain HA level in α-FMH-pretreated mice. Morphine administered alone significantly reduced the HA level in the spinal cord, an area where the turnover of HA is very slow. These results suggest that the acute morphine treatment increases the turnover of neuronal HA via opioid receptors, and this opiate also releases HA from a slowly turning over pool(s).

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalJournal of Neurochemistry
Volume45
Issue number3
Publication statusPublished - 1985

Fingerprint

Morphine
Histamine
Brain
Opiate Alkaloids
Spinal Cord
Histidine Decarboxylase
Pargyline
Histamine Release
Opioid Receptors
Naloxone
Metabolites

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Morphine-induced changes in histamine dynamics in mouse brain. / Nishibori, Masahiro; Oishi, R.; Itoh, Y.; Saeki, K.

In: Journal of Neurochemistry, Vol. 45, No. 3, 1985, p. 719-724.

Research output: Contribution to journalArticle

Nishibori, M, Oishi, R, Itoh, Y & Saeki, K 1985, 'Morphine-induced changes in histamine dynamics in mouse brain', Journal of Neurochemistry, vol. 45, no. 3, pp. 719-724.
Nishibori, Masahiro ; Oishi, R. ; Itoh, Y. ; Saeki, K. / Morphine-induced changes in histamine dynamics in mouse brain. In: Journal of Neurochemistry. 1985 ; Vol. 45, No. 3. pp. 719-724.
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