Mono- and dihydroxylated metabolites of thalidomide

Synthesis and TNF-α production-inhibitory activity

Takanori Nakamura, Tomomi Noguchi, Hisayoshi Kobayashi, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-α production inhibitor than thalidomide.

Original languageEnglish
Pages (from-to)1709-1714
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number12
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Thalidomide
Metabolites
Tumor Necrosis Factor-alpha
Leukemia
Cells
Cell Line
5,N-dihydroxythalidomide

Keywords

  • Hydroxythalidomide
  • Metabolite
  • Thalidomide
  • Tumor necrosis factor (TNF)-α modulator

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Mono- and dihydroxylated metabolites of thalidomide : Synthesis and TNF-α production-inhibitory activity. / Nakamura, Takanori; Noguchi, Tomomi; Kobayashi, Hisayoshi; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 54, No. 12, 2006, p. 1709-1714.

Research output: Contribution to journalArticle

Nakamura, Takanori ; Noguchi, Tomomi ; Kobayashi, Hisayoshi ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / Mono- and dihydroxylated metabolites of thalidomide : Synthesis and TNF-α production-inhibitory activity. In: Chemical and Pharmaceutical Bulletin. 2006 ; Vol. 54, No. 12. pp. 1709-1714.
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