Monitoring remineralization of enamel subsurface lesions by optical coherence tomography

Mona M. Mandurah, Alireza Sadr, Yasushi Shimada, Yuichi Kitasako, Syozi Nakashima, Turki A. Bakhsh, Junji Tagami, Yasunori Sumi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) is a potential clinical tool for enamel lesion monitoring. Sweptsource OCT findings were compared with cross-sectional nanohardness findings of enamel. Subsurface bovine enamel lesions in three groups were subjected to (1) deionized water (control), (2) phosphoryl oligosaccharide of calcium (POs-Ca) or (3) POs-Ca with 1 ppm fluoride for 14 days. B-scans images were obtained at 1310-nm center wavelength on sound, demineralized and remineralized areas after 4, 7, and 14 days. The specimens were processed for cross-sectional nanoindentation. Reflectivity from enamel that had increased with demineralization decreased with remineralization. An OCT attenuation coefficient parameter (μt), derived based on the Beer-Lambert law as a function of backscatter signal slope, showed a strong linear regression with integrated nanohardness of all regions (p < 0.001, r = ?0.97). Sound enamel showed the smallest, while demineralized enamel showed the highest μt. In group three, μt was significantly lower at four days than baseline, but remained constant afterwards. In group two, the changes were rather gradual. There was no significant difference between groups two and three at 14 days in nanohardness or μt POs-Ca with fluoride-enhanced nanohardness of the superficial zone. OCT signal attenuation demonstrated a capability for monitoring changes of enamel lesions during remineralization.

Original languageEnglish
Article number046006
JournalJournal of Biomedical Optics
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Fingerprint

enamels
Enamels
Optical tomography
lesions
Nanohardness
tomography
Monitoring
Oligosaccharides
calcium
Calcium
Fluorides
fluorides
Acoustic waves
Bouguer law
acoustics
Deionized water
attenuation coefficients
Nanoindentation
nanoindentation
Linear regression

Keywords

  • attenuation coefficient
  • Beer-Lambert law
  • enamel subsurface lesion
  • integrated nanohardness
  • nanoindentation
  • optical coherence tomography
  • phosphoryl oligosaccharide of calcium
  • remineralization

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Monitoring remineralization of enamel subsurface lesions by optical coherence tomography. / Mandurah, Mona M.; Sadr, Alireza; Shimada, Yasushi; Kitasako, Yuichi; Nakashima, Syozi; Bakhsh, Turki A.; Tagami, Junji; Sumi, Yasunori.

In: Journal of Biomedical Optics, Vol. 18, No. 4, 046006, 04.2013.

Research output: Contribution to journalArticle

Mandurah, MM, Sadr, A, Shimada, Y, Kitasako, Y, Nakashima, S, Bakhsh, TA, Tagami, J & Sumi, Y 2013, 'Monitoring remineralization of enamel subsurface lesions by optical coherence tomography', Journal of Biomedical Optics, vol. 18, no. 4, 046006. https://doi.org/10.1117/1.JBO.18.4.046006
Mandurah, Mona M. ; Sadr, Alireza ; Shimada, Yasushi ; Kitasako, Yuichi ; Nakashima, Syozi ; Bakhsh, Turki A. ; Tagami, Junji ; Sumi, Yasunori. / Monitoring remineralization of enamel subsurface lesions by optical coherence tomography. In: Journal of Biomedical Optics. 2013 ; Vol. 18, No. 4.
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