Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats

Toru Egashira, Fusako Takayama, Yasumitsu Yamanaka, Yasuhiro Komatsu

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13 Citations (Scopus)

Abstract

The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2 -), hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K(a) (absorption rate constant), T(max) (peak concentration time), T(1/2) (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2 -, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalJapanese Journal of Pharmacology
Volume80
Issue number4
DOIs
Publication statusPublished - 1999
Externally publishedYes

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Keywords

  • Pharmacodynamics
  • Radical scavenger
  • Sho-saiko-to (Kampo medicine)

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

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