The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2 -), hydroxyl radicals (·OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for K(a) (absorption rate constant), T(max) (peak concentration time), T(1/2) (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2 -, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.
- Radical scavenger
- Sho-saiko-to (Kampo medicine)
ASJC Scopus subject areas
- Molecular Medicine