Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation

Yoshinobu Maeda, Takanori Teshima, Masao Yamada, Katsuji Shinagawa, Shinji Nakao, Yuju Ohno, Kensuke Kojima, Masamichi Hara, Koji Nagafuji, Shin Hayashi, Shunnichi Fukuda, Hitoshi Sawada, Kosei Matsue, Katsuto Takenaka, Fumihiko Ishimaru, Kazuma Ikeda, Kenji Niiya, Mine Harada

Research output: Contribution to journalArticle

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Abstract

Herpesviruses frequently cause serious complications after allogeneic bone marrow transplantation (allo-BMT). Recent studies have shown more rapid immune reconstitution after allogeneic peripheral blood stem cell transplantation (allo-PBSCT) compared with allo-BMT. However, it has not been clarified whether the improved immune reconstitution after allo-PBSCT is associated with a lower incidence of herpesvirus infections. We monitored the emergence of Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6) and HHV-7 DNA by a nested-double polymerase chain reaction in peripheral blood leucocytes from 22 allo-BMT and 16 allo-PBSCT patients. Each virus had an unique temporal profile of detection. HHV-6 DNA was detected most frequently at 3 weeks after transplantation, whereas CMV and EBV DNA were detected later (2-3 months). Detection rates of HHV-6 DNA at 3 and 4 weeks after allo-BMT were significantly higher than those after allo- PBSCT (9/16 v 2/13 at 3 weeks. P <0.01; 10/21 v 1/15 at 4 weeks, P <0.01). Detection rates of the other three herpesviruses after the two types of allogeneic transplantation were not significantly different throughout observation period. Furthermore, detection of HHV-6 DNA within the first 4 weeks was associated with delayed platelet engraftment after both allo-BMT and allo-PBSCT (P

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalBritish Journal of Haematology
Volume105
Issue number1
DOIs
Publication statusPublished - 1999

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Peripheral Blood Stem Cell Transplantation
Herpesviridae
Homologous Transplantation
Bone Marrow Transplantation
Human Herpesvirus 6
DNA
Cytomegalovirus
Human Herpesvirus 4
Human Herpesvirus 7
Herpesviridae Infections
Leukocytes
Blood Platelets
Transplantation
Observation
Viruses
Polymerase Chain Reaction
Incidence

Keywords

  • Allogeneic PBSCT
  • CMV
  • Engraftment
  • Herpesvirus
  • HHV-6

ASJC Scopus subject areas

  • Hematology

Cite this

Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation. / Maeda, Yoshinobu; Teshima, Takanori; Yamada, Masao; Shinagawa, Katsuji; Nakao, Shinji; Ohno, Yuju; Kojima, Kensuke; Hara, Masamichi; Nagafuji, Koji; Hayashi, Shin; Fukuda, Shunnichi; Sawada, Hitoshi; Matsue, Kosei; Takenaka, Katsuto; Ishimaru, Fumihiko; Ikeda, Kazuma; Niiya, Kenji; Harada, Mine.

In: British Journal of Haematology, Vol. 105, No. 1, 1999, p. 295-302.

Research output: Contribution to journalArticle

Maeda, Y, Teshima, T, Yamada, M, Shinagawa, K, Nakao, S, Ohno, Y, Kojima, K, Hara, M, Nagafuji, K, Hayashi, S, Fukuda, S, Sawada, H, Matsue, K, Takenaka, K, Ishimaru, F, Ikeda, K, Niiya, K & Harada, M 1999, 'Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation', British Journal of Haematology, vol. 105, no. 1, pp. 295-302. https://doi.org/10.1111/j.1365-2141.1999.01290.x
Maeda, Yoshinobu ; Teshima, Takanori ; Yamada, Masao ; Shinagawa, Katsuji ; Nakao, Shinji ; Ohno, Yuju ; Kojima, Kensuke ; Hara, Masamichi ; Nagafuji, Koji ; Hayashi, Shin ; Fukuda, Shunnichi ; Sawada, Hitoshi ; Matsue, Kosei ; Takenaka, Katsuto ; Ishimaru, Fumihiko ; Ikeda, Kazuma ; Niiya, Kenji ; Harada, Mine. / Monitoring of human herpesviruses after allogeneic peripheral blood stem cell transplantation and bone marrow transplantation. In: British Journal of Haematology. 1999 ; Vol. 105, No. 1. pp. 295-302.
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AU - Ohno, Yuju

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AU - Sawada, Hitoshi

AU - Matsue, Kosei

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AU - Ikeda, Kazuma

AU - Niiya, Kenji

AU - Harada, Mine

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