Molybdenum oxides as highly effective dehydrative cyclization catalysts for the synthesis of oxazolines and thiazolines

Akira Sakakura, Rei Kondo, Kazuaki Ishihara

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

(Chemical Equation Presented) In the presence of molybdenum oxide the dehydrative cyclization of N-acylserines, N-acylthreonines, and N-acylcysteines can be carried out under Dean-Stark conditions in toluene to give oxazolines and thiazolines. The ammonium salts (NH4)6Mo 7O24·4H2O and (NH4) 2MoO4 have excellent catalytic activities for the dehydrative cyclization of serine and threonine derivatives, and the acetylacetonate complex MoO2(acac)2 has a remarkable catalytic activity for the dehydrative cyclization of cysteine derivatives. In addition, polyaniline-supported MoO2(acac)2 can easily be recovered and reused.

Original languageEnglish
Pages (from-to)1971-1974
Number of pages4
JournalOrganic Letters
Volume7
Issue number10
DOIs
Publication statusPublished - May 12 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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