Molecular therapy for human cancer with tumor suppressor p53 gene transfer

T. Fujiwara, F. Inoue, N. Tanaka

Research output: Contribution to journalArticle

Abstract

Molecular level approaches have demonstrated that tumor suppressor p53 gene, which is the most commonly mutated gene yet described in human cancers, plays an important role in the pathway of apoptosis triggered by DNA-damaging agents. In addition, defects in apoptosis caused by the inactivation of p53 resulted in resistance to treatment. Human gene therapy has become a reality with the development of effective techniques for delivering the gene to the target cells. These findings suggested a novel approach to cancer therapy with the direct delivery of wild-type p53 gene construct to cancer cells by using an adenoviral vector system. Restoration of wild-type p53 function markedly enhanced the antitumor effect of a common chemotherapeutic agent, cisplatin, in human non-small cell lung cancer cells as well as human colon cancer cells. The application of this technology to human cancer therapy is now in progress.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume25
Issue number2
Publication statusPublished - Jan 1998

Fingerprint

p53 Genes
Tumor Suppressor Genes
Neoplasms
Apoptosis
Therapeutics
Non-Small Cell Lung Carcinoma
Genetic Therapy
Colonic Neoplasms
Cisplatin
Genes
Technology
DNA

Keywords

  • Apoptosis
  • Cancer
  • Gene Therapy
  • P53

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Molecular therapy for human cancer with tumor suppressor p53 gene transfer. / Fujiwara, T.; Inoue, F.; Tanaka, N.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 25, No. 2, 01.1998, p. 194-200.

Research output: Contribution to journalArticle

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