Abstract
Molecular level approaches have demonstrated that tumor suppressor p53 gene, which is the most commonly mutated gene yet described in human cancers, plays an important role in the pathway of apoptosis triggered by DNA-damaging agents. In addition, defects in apoptosis caused by the inactivation of p53 resulted in resistance to treatment. Human gene therapy has become a reality with the development of effective techniques for delivering the gene to the target cells. These findings suggested a novel approach to cancer therapy with the direct delivery of wild-type p53 gene construct to cancer cells by using an adenoviral vector system. Restoration of wild-type p53 function markedly enhanced the antitumor effect of a common chemotherapeutic agent, cisplatin, in human non-small cell lung cancer cells as well as human colon cancer cells. The application of this technology to human cancer therapy is now in progress.
| Original language | English |
|---|---|
| Pages (from-to) | 194-200 |
| Number of pages | 7 |
| Journal | Gan to kagaku ryoho. Cancer & chemotherapy |
| Volume | 25 |
| Issue number | 2 |
| Publication status | Published - Jan 1998 |
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Keywords
- Apoptosis
- Cancer
- Gene Therapy
- P53
ASJC Scopus subject areas
- Cancer Research
- Pharmacology
Cite this
Molecular therapy for human cancer with tumor suppressor p53 gene transfer. / Fujiwara, T.; Inoue, F.; Tanaka, N.
In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 25, No. 2, 01.1998, p. 194-200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular therapy for human cancer with tumor suppressor p53 gene transfer
AU - Fujiwara, T.
AU - Inoue, F.
AU - Tanaka, N.
PY - 1998/1
Y1 - 1998/1
N2 - Molecular level approaches have demonstrated that tumor suppressor p53 gene, which is the most commonly mutated gene yet described in human cancers, plays an important role in the pathway of apoptosis triggered by DNA-damaging agents. In addition, defects in apoptosis caused by the inactivation of p53 resulted in resistance to treatment. Human gene therapy has become a reality with the development of effective techniques for delivering the gene to the target cells. These findings suggested a novel approach to cancer therapy with the direct delivery of wild-type p53 gene construct to cancer cells by using an adenoviral vector system. Restoration of wild-type p53 function markedly enhanced the antitumor effect of a common chemotherapeutic agent, cisplatin, in human non-small cell lung cancer cells as well as human colon cancer cells. The application of this technology to human cancer therapy is now in progress.
AB - Molecular level approaches have demonstrated that tumor suppressor p53 gene, which is the most commonly mutated gene yet described in human cancers, plays an important role in the pathway of apoptosis triggered by DNA-damaging agents. In addition, defects in apoptosis caused by the inactivation of p53 resulted in resistance to treatment. Human gene therapy has become a reality with the development of effective techniques for delivering the gene to the target cells. These findings suggested a novel approach to cancer therapy with the direct delivery of wild-type p53 gene construct to cancer cells by using an adenoviral vector system. Restoration of wild-type p53 function markedly enhanced the antitumor effect of a common chemotherapeutic agent, cisplatin, in human non-small cell lung cancer cells as well as human colon cancer cells. The application of this technology to human cancer therapy is now in progress.
KW - Apoptosis
KW - Cancer
KW - Gene Therapy
KW - P53
UR - http://www.scopus.com/inward/record.url?scp=0031600868&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031600868&partnerID=8YFLogxK
M3 - Article
VL - 25
SP - 194
EP - 200
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 2
ER -