Molecular subtypes of breast cancers from Myanmar women: A study of 91 cases at two pathology centers

Thar Htet San, Masayoshi Fujisawa, Soichiro Fushimi, Lamin Soe, Ngu Wah Min, Teizo Yoshimura, Toshiaki Ohara, Myint Myint Yee, Shinsuke Oda, Akihiro Matsukawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Breast cancer is the most common cancer in Myanmar women. Revealing the hormonal receptor status, human epidermal growth factor receptor 2 (HER2) and Ki-67 expression is useful for estimating patient prognosis as well as determination of treatment strategy. However, immunohistochemical features and classification of molecular subtypes in breast cancers from Myanmar remain unknown. Methods: The clinicopathological features of 91 breast cancers from Myanmar women were examined. Immunohistochemistry was performed on tissue specimens with antibodies to estrogen receptor (ER), progesterone receptor (PgR), HER2, Ki-67, cytokeratin (CK)5/6 and CK14. Immunohistochemistry-based molecular subtyping was conducted. Results: Breast cancers in Myanmar women were relatively large, high grade with frequent metastatic lymph nodes. Of the 91 patients, tumors with ER positive, PgR positive, and HER2 positive were 57.1%, 37.4%, and 28.6%, respectively. The most prevalent subtype was luminal B (HER2-) (39.6%), followed by HER2 (22.0%), triple negative (TN)-basal-like (12.1%), luminal A (11.0%), TN-null (8.8%) and luminal B (HER2+) (6.6%). The mean Ki-67 expression of 91 cases was 33.9% (33.9% ± 19.2%) and the median was 28% (range; 4%-90%). The mean Ki-67 expression of luminal A, luminal B, HER2 and TN-basal-like/ null was 7%, 30%, 40%, and 57%/43%, respectively. A higher Ki-67 expression significantly correlated with a higher grade, larger size and higher stage of malignancy. Conclusions: We, for the first time, investigated the histopathological features of breast cancers from Myanmar women. Myanmar breast cancers appeared to be aggressive in nature, as evidenced by high frequency of poor-prognosis subtypes with high level of Ki-67 expression.

Original languageEnglish
Pages (from-to)1617-1621
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume18
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Myanmar
Pathology
Breast Neoplasms
Progesterone Receptors
Estrogen Receptors
Immunohistochemistry
Keratin-6
Keratin-5
Neoplasms
human ERBB2 protein
Lymph Nodes
Antibodies

Keywords

  • Breast cancer
  • Ki-67 expression
  • Molecular subtypes
  • Myanmar

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Molecular subtypes of breast cancers from Myanmar women : A study of 91 cases at two pathology centers. / San, Thar Htet; Fujisawa, Masayoshi; Fushimi, Soichiro; Soe, Lamin; Min, Ngu Wah; Yoshimura, Teizo; Ohara, Toshiaki; Yee, Myint Myint; Oda, Shinsuke; Matsukawa, Akihiro.

In: Asian Pacific Journal of Cancer Prevention, Vol. 18, No. 6, 01.06.2017, p. 1617-1621.

Research output: Contribution to journalArticle

@article{511020c6a5b04f0b96055a1f287faf20,
title = "Molecular subtypes of breast cancers from Myanmar women: A study of 91 cases at two pathology centers",
abstract = "Background: Breast cancer is the most common cancer in Myanmar women. Revealing the hormonal receptor status, human epidermal growth factor receptor 2 (HER2) and Ki-67 expression is useful for estimating patient prognosis as well as determination of treatment strategy. However, immunohistochemical features and classification of molecular subtypes in breast cancers from Myanmar remain unknown. Methods: The clinicopathological features of 91 breast cancers from Myanmar women were examined. Immunohistochemistry was performed on tissue specimens with antibodies to estrogen receptor (ER), progesterone receptor (PgR), HER2, Ki-67, cytokeratin (CK)5/6 and CK14. Immunohistochemistry-based molecular subtyping was conducted. Results: Breast cancers in Myanmar women were relatively large, high grade with frequent metastatic lymph nodes. Of the 91 patients, tumors with ER positive, PgR positive, and HER2 positive were 57.1{\%}, 37.4{\%}, and 28.6{\%}, respectively. The most prevalent subtype was luminal B (HER2-) (39.6{\%}), followed by HER2 (22.0{\%}), triple negative (TN)-basal-like (12.1{\%}), luminal A (11.0{\%}), TN-null (8.8{\%}) and luminal B (HER2+) (6.6{\%}). The mean Ki-67 expression of 91 cases was 33.9{\%} (33.9{\%} ± 19.2{\%}) and the median was 28{\%} (range; 4{\%}-90{\%}). The mean Ki-67 expression of luminal A, luminal B, HER2 and TN-basal-like/ null was 7{\%}, 30{\%}, 40{\%}, and 57{\%}/43{\%}, respectively. A higher Ki-67 expression significantly correlated with a higher grade, larger size and higher stage of malignancy. Conclusions: We, for the first time, investigated the histopathological features of breast cancers from Myanmar women. Myanmar breast cancers appeared to be aggressive in nature, as evidenced by high frequency of poor-prognosis subtypes with high level of Ki-67 expression.",
keywords = "Breast cancer, Ki-67 expression, Molecular subtypes, Myanmar",
author = "San, {Thar Htet} and Masayoshi Fujisawa and Soichiro Fushimi and Lamin Soe and Min, {Ngu Wah} and Teizo Yoshimura and Toshiaki Ohara and Yee, {Myint Myint} and Shinsuke Oda and Akihiro Matsukawa",
year = "2017",
month = "6",
day = "1",
doi = "10.22034/APJCP.2017.18.6.1617",
language = "English",
volume = "18",
pages = "1617--1621",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "6",

}

TY - JOUR

T1 - Molecular subtypes of breast cancers from Myanmar women

T2 - A study of 91 cases at two pathology centers

AU - San, Thar Htet

AU - Fujisawa, Masayoshi

AU - Fushimi, Soichiro

AU - Soe, Lamin

AU - Min, Ngu Wah

AU - Yoshimura, Teizo

AU - Ohara, Toshiaki

AU - Yee, Myint Myint

AU - Oda, Shinsuke

AU - Matsukawa, Akihiro

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Breast cancer is the most common cancer in Myanmar women. Revealing the hormonal receptor status, human epidermal growth factor receptor 2 (HER2) and Ki-67 expression is useful for estimating patient prognosis as well as determination of treatment strategy. However, immunohistochemical features and classification of molecular subtypes in breast cancers from Myanmar remain unknown. Methods: The clinicopathological features of 91 breast cancers from Myanmar women were examined. Immunohistochemistry was performed on tissue specimens with antibodies to estrogen receptor (ER), progesterone receptor (PgR), HER2, Ki-67, cytokeratin (CK)5/6 and CK14. Immunohistochemistry-based molecular subtyping was conducted. Results: Breast cancers in Myanmar women were relatively large, high grade with frequent metastatic lymph nodes. Of the 91 patients, tumors with ER positive, PgR positive, and HER2 positive were 57.1%, 37.4%, and 28.6%, respectively. The most prevalent subtype was luminal B (HER2-) (39.6%), followed by HER2 (22.0%), triple negative (TN)-basal-like (12.1%), luminal A (11.0%), TN-null (8.8%) and luminal B (HER2+) (6.6%). The mean Ki-67 expression of 91 cases was 33.9% (33.9% ± 19.2%) and the median was 28% (range; 4%-90%). The mean Ki-67 expression of luminal A, luminal B, HER2 and TN-basal-like/ null was 7%, 30%, 40%, and 57%/43%, respectively. A higher Ki-67 expression significantly correlated with a higher grade, larger size and higher stage of malignancy. Conclusions: We, for the first time, investigated the histopathological features of breast cancers from Myanmar women. Myanmar breast cancers appeared to be aggressive in nature, as evidenced by high frequency of poor-prognosis subtypes with high level of Ki-67 expression.

AB - Background: Breast cancer is the most common cancer in Myanmar women. Revealing the hormonal receptor status, human epidermal growth factor receptor 2 (HER2) and Ki-67 expression is useful for estimating patient prognosis as well as determination of treatment strategy. However, immunohistochemical features and classification of molecular subtypes in breast cancers from Myanmar remain unknown. Methods: The clinicopathological features of 91 breast cancers from Myanmar women were examined. Immunohistochemistry was performed on tissue specimens with antibodies to estrogen receptor (ER), progesterone receptor (PgR), HER2, Ki-67, cytokeratin (CK)5/6 and CK14. Immunohistochemistry-based molecular subtyping was conducted. Results: Breast cancers in Myanmar women were relatively large, high grade with frequent metastatic lymph nodes. Of the 91 patients, tumors with ER positive, PgR positive, and HER2 positive were 57.1%, 37.4%, and 28.6%, respectively. The most prevalent subtype was luminal B (HER2-) (39.6%), followed by HER2 (22.0%), triple negative (TN)-basal-like (12.1%), luminal A (11.0%), TN-null (8.8%) and luminal B (HER2+) (6.6%). The mean Ki-67 expression of 91 cases was 33.9% (33.9% ± 19.2%) and the median was 28% (range; 4%-90%). The mean Ki-67 expression of luminal A, luminal B, HER2 and TN-basal-like/ null was 7%, 30%, 40%, and 57%/43%, respectively. A higher Ki-67 expression significantly correlated with a higher grade, larger size and higher stage of malignancy. Conclusions: We, for the first time, investigated the histopathological features of breast cancers from Myanmar women. Myanmar breast cancers appeared to be aggressive in nature, as evidenced by high frequency of poor-prognosis subtypes with high level of Ki-67 expression.

KW - Breast cancer

KW - Ki-67 expression

KW - Molecular subtypes

KW - Myanmar

UR - http://www.scopus.com/inward/record.url?scp=85021448764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021448764&partnerID=8YFLogxK

U2 - 10.22034/APJCP.2017.18.6.1617

DO - 10.22034/APJCP.2017.18.6.1617

M3 - Article

C2 - 28670879

AN - SCOPUS:85021448764

VL - 18

SP - 1617

EP - 1621

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 6

ER -