Molecular structure of the Japanese hepatitis C viral genome

Nobuyuki Kato, Makoto Hijikata, Mosanori Nakagawa, Yuko Ootsuyama, Kanae Muraiso, Showgo Ohkoshi, Kunitada Shimotohno

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et. al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524-9528)indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase. NTPase and RNA-dependent RNA polymerase.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalFEBS Letters
Volume280
Issue number2
DOIs
Publication statusPublished - Mar 25 1991
Externally publishedYes

Keywords

  • Amino acid sequence.
  • HCV-J
  • Non-A, non-B hepatitis
  • RNA virus

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • Cite this

    Kato, N., Hijikata, M., Nakagawa, M., Ootsuyama, Y., Muraiso, K., Ohkoshi, S., & Shimotohno, K. (1991). Molecular structure of the Japanese hepatitis C viral genome. FEBS Letters, 280(2), 325-328. https://doi.org/10.1016/0014-5793(91)80322-T