Abstract
Tau protein is a major component of neurofibrillary tangles (NFTs) in Alzheimer's disease. Mutations in the tau gene cause frontotemporal dementia linked to chromosome 17 (FTDP-17). Tau filament formation without Aβ accumulation is one of the characteristics of FTDP-17. Discovery of mutations in the gene demonstrated that dysfunction of tau can cause neurodegeneration and dementia. Several lines of transgenic (Tg) mice carrying tau mutations found in families with FTDP-17 have been generated to clarify the mechanism of Alzheimer's disease and other neurodegenerative disorders characterized by aberrant accumulation of tau protein in the central nervous system (tauopathy). In the present article, we make a review on transgenic tau mice, which would be of great help for the solution of molecular pathology and the establishment of therapeutics for tauopathy.
| Original language | English |
|---|---|
| Pages (from-to) | 379-382 |
| Number of pages | 4 |
| Journal | International Congress Series |
| Volume | 1252 |
| Issue number | C |
| DOIs | |
| Publication status | Published - Jun 1 2003 |
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Keywords
- Frontotemporal dementia linked to chromosome 17 (FTDP-17)
- Mutation
- Tau
- Transgenic mice
ASJC Scopus subject areas
- Medicine(all)
Cite this
Molecular pathology of transgenic tau mice. / Murakami, Tetsuro; Kawarabayashi, Takeshi; Matsubara, Etsuro; Shoji, Mikio; Abe, Koji.
In: International Congress Series, Vol. 1252, No. C, 01.06.2003, p. 379-382.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular pathology of transgenic tau mice
AU - Murakami, Tetsuro
AU - Kawarabayashi, Takeshi
AU - Matsubara, Etsuro
AU - Shoji, Mikio
AU - Abe, Koji
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Tau protein is a major component of neurofibrillary tangles (NFTs) in Alzheimer's disease. Mutations in the tau gene cause frontotemporal dementia linked to chromosome 17 (FTDP-17). Tau filament formation without Aβ accumulation is one of the characteristics of FTDP-17. Discovery of mutations in the gene demonstrated that dysfunction of tau can cause neurodegeneration and dementia. Several lines of transgenic (Tg) mice carrying tau mutations found in families with FTDP-17 have been generated to clarify the mechanism of Alzheimer's disease and other neurodegenerative disorders characterized by aberrant accumulation of tau protein in the central nervous system (tauopathy). In the present article, we make a review on transgenic tau mice, which would be of great help for the solution of molecular pathology and the establishment of therapeutics for tauopathy.
AB - Tau protein is a major component of neurofibrillary tangles (NFTs) in Alzheimer's disease. Mutations in the tau gene cause frontotemporal dementia linked to chromosome 17 (FTDP-17). Tau filament formation without Aβ accumulation is one of the characteristics of FTDP-17. Discovery of mutations in the gene demonstrated that dysfunction of tau can cause neurodegeneration and dementia. Several lines of transgenic (Tg) mice carrying tau mutations found in families with FTDP-17 have been generated to clarify the mechanism of Alzheimer's disease and other neurodegenerative disorders characterized by aberrant accumulation of tau protein in the central nervous system (tauopathy). In the present article, we make a review on transgenic tau mice, which would be of great help for the solution of molecular pathology and the establishment of therapeutics for tauopathy.
KW - Frontotemporal dementia linked to chromosome 17 (FTDP-17)
KW - Mutation
KW - Tau
KW - Transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=85023082358&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85023082358&partnerID=8YFLogxK
U2 - 10.1016/S0531-5131(03)00084-0
DO - 10.1016/S0531-5131(03)00084-0
M3 - Article
AN - SCOPUS:85023082358
VL - 1252
SP - 379
EP - 382
JO - International Congress Series
JF - International Congress Series
SN - 0531-5131
IS - C
ER -