3 Citations (Scopus)

Abstract

Cardiac involvement has a profound effect on the prognosis of patients with systemic amyloidosis. Therapeutic methods for suppressing the production of causative proteins have been developed for ATTR amyloidosis and AL amyloidosis, which show cardiac involvement, and the prognosis has been improved. However, a method for removing deposited amyloid has not been established. Methods for reducing cytotoxicity caused by amyloid deposition and amyloid precur-sor protein to protect cardiovascular cells are also needed. In this review, we outline the molecular mechanisms and treatments of cardiac amyloidosis.

Original languageEnglish
Article number25
JournalInternational journal of molecular sciences
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 2022

Keywords

  • Amyloid
  • Cytotoxicity
  • Immunoglobulin light chain
  • Transthyretin

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Molecular mechanisms of cardiac amyloidosis'. Together they form a unique fingerprint.

Cite this