Molecular evolution of yeast thiolase isozymes

Naoki Kanayama, Mitsuyoshi Ueda, Haruyuki Atomi, Tatsuo Kurihara, Atsuo Tanaka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The coexistence of two thiolase isozymes (acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase), essential for the complete degradation of fatty acids, only in peroxisomes of an n-alkane-utilizing yeast Candida tropicalis (Kurihara et al., J. Biochem., 106, 474-478, 1989) is unique in eukaryotic cells. As one of the methods of analysis of molecular information from these isozymes, the calculation of the evolutional distance among thiolases from various organisms suggested that yeast peroxisomal thiolase isozymes are important enzymes in examining the molecular evolution of the fatty acid metabolic pathway and the biogenesis of peroxisomes.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalJournal of Fermentation and Bioengineering
Volume78
Issue number4
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Molecular Evolution
Fatty acids
Yeast
Isoenzymes
Peroxisomes
Yeasts
Candida
Acetyl-CoA C-Acetyltransferase
Fatty Acids
Acetyl-CoA C-Acyltransferase
Paraffins
Candida tropicalis
Alkanes
Enzymes
Eukaryotic Cells
Metabolic Networks and Pathways
Degradation

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Molecular evolution of yeast thiolase isozymes. / Kanayama, Naoki; Ueda, Mitsuyoshi; Atomi, Haruyuki; Kurihara, Tatsuo; Tanaka, Atsuo.

In: Journal of Fermentation and Bioengineering, Vol. 78, No. 4, 1994, p. 279-282.

Research output: Contribution to journalArticle

Kanayama, Naoki ; Ueda, Mitsuyoshi ; Atomi, Haruyuki ; Kurihara, Tatsuo ; Tanaka, Atsuo. / Molecular evolution of yeast thiolase isozymes. In: Journal of Fermentation and Bioengineering. 1994 ; Vol. 78, No. 4. pp. 279-282.
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