TY - JOUR
T1 - Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients
AU - Kagawa, Shunsuke
AU - Shigeyasu, Kunitoshi
AU - Ishida, Michihiro
AU - Watanabe, Megumi
AU - Tazawa, Hiroshi
AU - Nagasaka, Takeshi
AU - Shirakawa, Yasuhiro
AU - Fujiwara, Toshiyoshi
N1 - Publisher Copyright:
© 2014 Baishideng Publishing Group Inc. All rights reserved.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014/12/21
Y1 - 2014/12/21
N2 - To apply an individualized oncological approach to gastric cancer patients, the accurate diagnosis of disease entities is required. Peritoneal metastasis is the most frequent mode of metastasis in gastric cancer, and the tumor-node-metastasis classification includes cytological detection of intraperitoneal cancer cells as part of the staging process, denoting metastatic disease. The accuracy of cytological diagnosis leaves room for improvement; therefore, highly sensitive molecular diagnostics, such as an enzyme immunoassay, reverse transcription polymerase chain reaction, and virusguided imaging, have been developed to detect minute cancer cells in the peritoneal cavity. Molecular targeting therapy has also been spun off from basic research in the past decade. Although conventional cytology is still the mainstay, novel approaches could serve as practical complementary diagnostics to cytology in near future.
AB - To apply an individualized oncological approach to gastric cancer patients, the accurate diagnosis of disease entities is required. Peritoneal metastasis is the most frequent mode of metastasis in gastric cancer, and the tumor-node-metastasis classification includes cytological detection of intraperitoneal cancer cells as part of the staging process, denoting metastatic disease. The accuracy of cytological diagnosis leaves room for improvement; therefore, highly sensitive molecular diagnostics, such as an enzyme immunoassay, reverse transcription polymerase chain reaction, and virusguided imaging, have been developed to detect minute cancer cells in the peritoneal cavity. Molecular targeting therapy has also been spun off from basic research in the past decade. Although conventional cytology is still the mainstay, novel approaches could serve as practical complementary diagnostics to cytology in near future.
KW - Carcinoembryonic antigen
KW - Cytology
KW - Gastric cancer
KW - Molecular diagnostic techniques
KW - Peritoneal lavage
KW - Reverse transcriptase polymerase chain reaction
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U2 - 10.3748/wjg.v20.i47.17796
DO - 10.3748/wjg.v20.i47.17796
M3 - Article
C2 - 25548478
AN - SCOPUS:84919773525
VL - 20
SP - 17796
EP - 17803
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 47
ER -