Abstract
To apply an individualized oncological approach to gastric cancer patients, the accurate diagnosis of disease entities is required. Peritoneal metastasis is the most frequent mode of metastasis in gastric cancer, and the tumor-node-metastasis classification includes cytological detection of intraperitoneal cancer cells as part of the staging process, denoting metastatic disease. The accuracy of cytological diagnosis leaves room for improvement; therefore, highly sensitive molecular diagnostics, such as an enzyme immunoassay, reverse transcription polymerase chain reaction, and virusguided imaging, have been developed to detect minute cancer cells in the peritoneal cavity. Molecular targeting therapy has also been spun off from basic research in the past decade. Although conventional cytology is still the mainstay, novel approaches could serve as practical complementary diagnostics to cytology in near future.
| Original language | English |
|---|---|
| Pages (from-to) | 17796-17803 |
| Number of pages | 8 |
| Journal | World Journal of Gastroenterology |
| Volume | 20 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - Dec 21 2014 |
Fingerprint
Keywords
- Carcinoembryonic antigen
- Cytology
- Gastric cancer
- Molecular diagnostic techniques
- Peritoneal lavage
- Reverse transcriptase polymerase chain reaction
ASJC Scopus subject areas
- Gastroenterology
Cite this
Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients. / Kagawa, Shunsuke; Shigeyasu, Kunitoshi; Ishida, Michihiro; Watanabe, Megumi; Tazawa, Hiroshi; Nagasaka, Takeshi; Shirakawa, Yasuhiro; Fujiwara, Toshiyoshi.
In: World Journal of Gastroenterology, Vol. 20, No. 47, 21.12.2014, p. 17796-17803.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients
AU - Kagawa, Shunsuke
AU - Shigeyasu, Kunitoshi
AU - Ishida, Michihiro
AU - Watanabe, Megumi
AU - Tazawa, Hiroshi
AU - Nagasaka, Takeshi
AU - Shirakawa, Yasuhiro
AU - Fujiwara, Toshiyoshi
PY - 2014/12/21
Y1 - 2014/12/21
N2 - To apply an individualized oncological approach to gastric cancer patients, the accurate diagnosis of disease entities is required. Peritoneal metastasis is the most frequent mode of metastasis in gastric cancer, and the tumor-node-metastasis classification includes cytological detection of intraperitoneal cancer cells as part of the staging process, denoting metastatic disease. The accuracy of cytological diagnosis leaves room for improvement; therefore, highly sensitive molecular diagnostics, such as an enzyme immunoassay, reverse transcription polymerase chain reaction, and virusguided imaging, have been developed to detect minute cancer cells in the peritoneal cavity. Molecular targeting therapy has also been spun off from basic research in the past decade. Although conventional cytology is still the mainstay, novel approaches could serve as practical complementary diagnostics to cytology in near future.
AB - To apply an individualized oncological approach to gastric cancer patients, the accurate diagnosis of disease entities is required. Peritoneal metastasis is the most frequent mode of metastasis in gastric cancer, and the tumor-node-metastasis classification includes cytological detection of intraperitoneal cancer cells as part of the staging process, denoting metastatic disease. The accuracy of cytological diagnosis leaves room for improvement; therefore, highly sensitive molecular diagnostics, such as an enzyme immunoassay, reverse transcription polymerase chain reaction, and virusguided imaging, have been developed to detect minute cancer cells in the peritoneal cavity. Molecular targeting therapy has also been spun off from basic research in the past decade. Although conventional cytology is still the mainstay, novel approaches could serve as practical complementary diagnostics to cytology in near future.
KW - Carcinoembryonic antigen
KW - Cytology
KW - Gastric cancer
KW - Molecular diagnostic techniques
KW - Peritoneal lavage
KW - Reverse transcriptase polymerase chain reaction
UR - http://www.scopus.com/inward/record.url?scp=84919773525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919773525&partnerID=8YFLogxK
U2 - 10.3748/wjg.v20.i47.17796
DO - 10.3748/wjg.v20.i47.17796
M3 - Article
C2 - 25548478
AN - SCOPUS:84919773525
VL - 20
SP - 17796
EP - 17803
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 47
ER -