Abstract
Southern blot analysis with a cDNA probe of MLL indicated that the breakpoint is in a BamHI:8.3kb fragment which carries the exon 5-11 of MLL gene in DNA from an adult acute myelomonocytic leukaemia with a t(11;22)(q23,q11) translocation. The structural analysis of the rearranged MLL locus demonstrated that the breakpoint is localized between exon 8 and 9 of MLL locus. The normal counterpart fused to the MLL locus was proved to be derived from chromosome 22q11(AF-22) by somatic cell hybrids analysis and FISH. By FISH, AF-22 locus was localized to the region more centromeric to the BCR gene.
| Original language | English |
|---|---|
| Pages (from-to) | 687-691 |
| Number of pages | 5 |
| Journal | British Journal of Haematology |
| Volume | 92 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1996 |
Keywords
- 11q23
- AF-22
- Acute myelomonocytic leukaemia
- MLL
- t(11,22)(q23,q11)
ASJC Scopus subject areas
- Hematology
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Cite this
Marukawa, O., Akao, Y., Inazawa, J., Ariyama, T., Abe, T., Naoe, T., Tanimoto, M., Saito, H., Otsuki, Y., & Tsujimoto, Y. (1996). Molecular cloning of the breakpoint of t(11;22)(q23;q11) chromosome translocation in an adult acute myelomonocytic leukaemia. British Journal of Haematology, 92(3), 687-691. https://doi.org/10.1046/j.1365-2141.1996.380916.x