Abstract
The cDNA encoding an entire open reading frame of rat betacellulin has been cloned from rat kidney. Expression of this cDNA in COS7 cells showed a significant amount of mitogenic activity in the culture media. Western blotting of the cell lysates suggested that the membrane-anchored precursor was cleaved to release its ectodomain very efficiently. Copyright (C) 2000.
| Original language | English |
|---|---|
| Pages (from-to) | 285-288 |
| Number of pages | 4 |
| Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
| Volume | 1492 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jun 21 2000 |
Keywords
- Betacellulin
- Epidermal growth factor family
- Membrane-anchored growth factor
- Pancreatic cell differentiation
- Secretase
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Genetics
Fingerprint Dive into the research topics of 'Molecular cloning and expression of rat betacellulin cDNA'. Together they form a unique fingerprint.
Cite this
Tada, H., Seno, M., Yamada, H., Sasada, R., & Igarashi, K. (2000). Molecular cloning and expression of rat betacellulin cDNA. Biochimica et Biophysica Acta - Gene Structure and Expression, 1492(1), 285-288. https://doi.org/10.1016/S0167-4781(00)00106-8