Molecular cloning and expression of rat betacellulin cDNA

Hiroko Tada; Masaharu Seno; Hidenori Yamada; Reiko Sasada; Koichi Igarashi

doi:10.1016/S0167-4781(00)00106-8

Molecular cloning and expression of rat betacellulin cDNA

Hiroko Tada, Masaharu Seno, Hidenori Yamada, Reiko Sasada, Koichi Igarashi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The cDNA encoding an entire open reading frame of rat betacellulin has been cloned from rat kidney. Expression of this cDNA in COS7 cells showed a significant amount of mitogenic activity in the culture media. Western blotting of the cell lysates suggested that the membrane-anchored precursor was cleaved to release its ectodomain very efficiently. Copyright (C) 2000.

Original language	English
Pages (from-to)	285-288
Number of pages	4
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1492
Issue number	1
DOIs	https://doi.org/10.1016/S0167-4781(00)00106-8
Publication status	Published - Jun 21 2000

Keywords

Betacellulin
Epidermal growth factor family
Membrane-anchored growth factor
Pancreatic cell differentiation
Secretase

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

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AU - Tada, Hiroko

AU - Seno, Masaharu

AU - Yamada, Hidenori

AU - Sasada, Reiko

AU - Igarashi, Koichi

PY - 2000/6/21

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KW - Pancreatic cell differentiation

KW - Secretase

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