Molecular cloning and expression of rat betacellulin cDNA

Hiroko Tada, Masaharu Seno, Hidenori Yamada, Reiko Sasada, Koichi Igarashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The cDNA encoding an entire open reading frame of rat betacellulin has been cloned from rat kidney. Expression of this cDNA in COS7 cells showed a significant amount of mitogenic activity in the culture media. Western blotting of the cell lysates suggested that the membrane-anchored precursor was cleaved to release its ectodomain very efficiently. Copyright (C) 2000.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1492
Issue number1
DOIs
Publication statusPublished - Jun 21 2000

Keywords

  • Betacellulin
  • Epidermal growth factor family
  • Membrane-anchored growth factor
  • Pancreatic cell differentiation
  • Secretase

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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