Molecular cloning and expression of rat betacellulin cDNA

Hiroko Tada, Masaharu Seno, Hidenori Yamada, Reiko Sasada, Koichi Igarashi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The cDNA encoding an entire open reading frame of rat betacellulin has been cloned from rat kidney. Expression of this cDNA in COS7 cells showed a significant amount of mitogenic activity in the culture media. Western blotting of the cell lysates suggested that the membrane-anchored precursor was cleaved to release its ectodomain very efficiently. Copyright (C) 2000.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Issue number1
Publication statusPublished - Jun 21 2000


  • Betacellulin
  • Epidermal growth factor family
  • Membrane-anchored growth factor
  • Pancreatic cell differentiation
  • Secretase

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics


Dive into the research topics of 'Molecular cloning and expression of rat betacellulin cDNA'. Together they form a unique fingerprint.

Cite this