Abstract
The cDNA encoding an entire open reading frame of rat betacellulin has been cloned from rat kidney. Expression of this cDNA in COS7 cells showed a significant amount of mitogenic activity in the culture media. Western blotting of the cell lysates suggested that the membrane-anchored precursor was cleaved to release its ectodomain very efficiently. Copyright (C) 2000.
Original language | English |
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Pages (from-to) | 285-288 |
Number of pages | 4 |
Journal | Biochimica et Biophysica Acta - Gene Structure and Expression |
Volume | 1492 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jun 21 2000 |
Keywords
- Betacellulin
- Epidermal growth factor family
- Membrane-anchored growth factor
- Pancreatic cell differentiation
- Secretase
ASJC Scopus subject areas
- Structural Biology
- Biophysics
- Biochemistry
- Genetics