Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface

Tomoyuki Honda, Masayuki Horie, Takuji Daito, Kazuyoshi Ikuta, Keizo Tomonaga

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Borna disease virus (BDV) is characterized by highly neurotropic infection. BDV enters its target cells using virus surface glycoprotein (G), but the cellular molecules mediating this process remain to be elucidated. We demonstrate here that the N-terminal product of G, GP1, interacts with the 78-kDa chaperone protein BiP. BiP was found at the surface of BDV-permissive cells, and anti-BiP antibody reduced BDV infection as well as GP1 binding to the cell surface. We also reveal that BiP localizes at the synapse of neurons. These results indicate that BiP may participate in the cell surface association of BDV.

Original languageEnglish
Pages (from-to)12622-12625
Number of pages4
JournalJournal of Virology
Volume83
Issue number23
DOIs
Publication statusPublished - Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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