Molecular and genetic basis of the regulation of dopamine transporter

Shigeo Kitayama, Chiharu Sogawa, Norio Sogawa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dopamine transporter (DAT) is a member of the solute carrier (SLC) gene family, such as the Na+/Cl- -dependent transporter subfamily, which participates in the reuptake of released neurotransmitter, thereby controlling the fine-tuning of neurotransmission. DAT as well as noradrenaline transporter and serotonin transporter are associated with psychiatric and neurological disorders, and are targets for antidepressants and drugs of abuse. Recent molecular, pharmacological and genetic approaches to the regulation of DAT have established its importance in the dopaminergic neurotransmission. These studies achieved the identification of intracellular signaling cascades leading to the control of DAT expression, function, trafficking, and degradation. In this chapter, we review the current knowledge about the role of DAT-associated proteins in the regulation of DAT expression and function. In addition, we discuss possible implication of DAT regulation to the vulnerability of dopaminergic neurons to the putative toxicity of certain drugs like amphetamine and factors involved in dopaminergic neurodegeneration. Understanding the molecular and genetic basis of the regulation of DAT is essential for contributing the identification of potential new targets for the treatment of various brain diseases including Parkinson's disease.

Original languageEnglish
Title of host publicationDopamine
Subtitle of host publicationFunctions, Regulation and Health Effects
PublisherNova Science Publishers, Inc.
Pages141-167
Number of pages27
ISBN (Print)9781619421479
Publication statusPublished - Dec 1 2012

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ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kitayama, S., Sogawa, C., & Sogawa, N. (2012). Molecular and genetic basis of the regulation of dopamine transporter. In Dopamine: Functions, Regulation and Health Effects (pp. 141-167). Nova Science Publishers, Inc..