Abstract
Nymphs of hemimetabolous insects such as cockroaches and crickets exhibit a remarkable capacity for regenerating complex structures from damaged legs. Until recent years, however, approaches to elucidate the molecular mechanisms underlying the leg regeneration process have been lacking. Taking the cricket Gryllus bimaculatus as a model, we found that a phenotype related to regeneration frequently appears during leg regeneration, even though no phenotype is induced by RNA interference (RNAi) in the cricket nymph, designated as regeneration-dependent RNAi. Since then, we have investigated the functions of various genes encoding signaling factors and cellular adhesion proteins like Fat and Dachsous during leg regeneration. In this review, we summarize the classical knowledge about insect leg regeneration and introduce recent advances concerning the signaling cascades required for regenerating a leg. Our results provide clues to the mechanisms of regeneration which are relevant to vertebrate systems.
| Original language | English |
|---|---|
| Pages (from-to) | 64-72 |
| Number of pages | 9 |
| Journal | Cellular and Molecular Life Sciences |
| Volume | 65 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
| Externally published | Yes |
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Keywords
- Fat signaling
- Gryllus bimaculatus
- Legs
- Positional information
- Regeneration
- Wnt signaling
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Cell Biology
Cite this
Molecular and cellular basis of regeneration and tissue repair : Dissecting insect leg regeneration through RNA interference. / Nakamura, T.; Mito, T.; Bando, Tetsuya; Ohuchi, Hideyo; Noji, S.
In: Cellular and Molecular Life Sciences, Vol. 65, No. 1, 01.2008, p. 64-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular and cellular basis of regeneration and tissue repair
T2 - Dissecting insect leg regeneration through RNA interference
AU - Nakamura, T.
AU - Mito, T.
AU - Bando, Tetsuya
AU - Ohuchi, Hideyo
AU - Noji, S.
PY - 2008/1
Y1 - 2008/1
N2 - Nymphs of hemimetabolous insects such as cockroaches and crickets exhibit a remarkable capacity for regenerating complex structures from damaged legs. Until recent years, however, approaches to elucidate the molecular mechanisms underlying the leg regeneration process have been lacking. Taking the cricket Gryllus bimaculatus as a model, we found that a phenotype related to regeneration frequently appears during leg regeneration, even though no phenotype is induced by RNA interference (RNAi) in the cricket nymph, designated as regeneration-dependent RNAi. Since then, we have investigated the functions of various genes encoding signaling factors and cellular adhesion proteins like Fat and Dachsous during leg regeneration. In this review, we summarize the classical knowledge about insect leg regeneration and introduce recent advances concerning the signaling cascades required for regenerating a leg. Our results provide clues to the mechanisms of regeneration which are relevant to vertebrate systems.
AB - Nymphs of hemimetabolous insects such as cockroaches and crickets exhibit a remarkable capacity for regenerating complex structures from damaged legs. Until recent years, however, approaches to elucidate the molecular mechanisms underlying the leg regeneration process have been lacking. Taking the cricket Gryllus bimaculatus as a model, we found that a phenotype related to regeneration frequently appears during leg regeneration, even though no phenotype is induced by RNA interference (RNAi) in the cricket nymph, designated as regeneration-dependent RNAi. Since then, we have investigated the functions of various genes encoding signaling factors and cellular adhesion proteins like Fat and Dachsous during leg regeneration. In this review, we summarize the classical knowledge about insect leg regeneration and introduce recent advances concerning the signaling cascades required for regenerating a leg. Our results provide clues to the mechanisms of regeneration which are relevant to vertebrate systems.
KW - Fat signaling
KW - Gryllus bimaculatus
KW - Legs
KW - Positional information
KW - Regeneration
KW - Wnt signaling
UR - http://www.scopus.com/inward/record.url?scp=38549162806&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38549162806&partnerID=8YFLogxK
U2 - 10.1007/s00018-007-7432-0
DO - 10.1007/s00018-007-7432-0
M3 - Article
C2 - 18030418
AN - SCOPUS:38549162806
VL - 65
SP - 64
EP - 72
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 1
ER -