Modulatory effect of a serine protease inhibitor on surgical stress: Its clinical implications

Hiromi Iwagaki, Takahito Yagi, Naoto Urushihara, Kenta Kobashi, Yoshinori Morimoto, Hiroshi Isozaki, Norihisa Takakura, Noriaki Tanaka

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5 Citations (Scopus)

Abstract

The relationship between endogenous cytokine antagonists and surgical stress is poorly understood. Surgical stress induces immunosuppression, and the reversed therapy of postoperative immunosuppression has been expected. The aim of the present study was to assess the effect of a serine protease inhibitor on postoperative immune reactivity. Twenty patients with colorectal cancer were randomly separated into experimental and control groups of 10 patients each. The experimental group received perioperative administration of a serine protease inhibitor while the control group did not. Plasma levels of cytokine antagonists, which suppress cell-mediated immunity, such as cortisol, interleukin-1 receptor antagonist, soluble interleukin-2 receptor (sIL-2R) and soluble tumor necrosis factors p55, p75 (sTNF-R55, -R75) were simultaneously measured. Significant reductions of plasma concentration of sIL-2R and sTNF-R55 were observed. Perioperative administration of a serine protease inhibitor may contribute to ameliorating immunosuppression after major surgery.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalActa Medica Okayama
Volume53
Issue number5
Publication statusPublished - 1999

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Keywords

  • Cytokine antagonist
  • Protease inhibitor
  • Surgical stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Iwagaki, H., Yagi, T., Urushihara, N., Kobashi, K., Morimoto, Y., Isozaki, H., Takakura, N., & Tanaka, N. (1999). Modulatory effect of a serine protease inhibitor on surgical stress: Its clinical implications. Acta Medica Okayama, 53(5), 239-244.