Modulation of T cell function by alpha-fetoprotein

An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein

Eiji Matsuura, Y. Kang, H. Kitakawa, A. Ogata, T. Kotani, S. Ohtaki, Shinzo Nishi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Experimental autoimmune thyroiditis was induced in transgenic mice (TG- 3) producing human α-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contrast, the development was significantly suppressed in TG-3 mice and mild histologic change was observed in only I out of 8 TG-3 mice (p <0.05). Serum anti-TPO antibody titers gradually increased in TG-3 mice as well as in control mice and there were no significant differences. In vitro phytohemagglutinin response of splenocytes from TG-3 mice was lower than that from control mice. Significantly reduced numbers of CD4+ and CD8+ splenocytes, total thymocytes, and CD4+ thymocytes were found in the nontreated TG-3 mice as compared with those in control mice. These results suggest that ubiquitously produced AFP modulates in vivo T cell development and/or T cell-dependent immune responses.

Original languageEnglish
Pages (from-to)162-171
Number of pages10
JournalTumor Biology
Volume20
Issue number3
DOIs
Publication statusPublished - May 1999

Fingerprint

Autoimmune Thyroiditis
Iodide Peroxidase
alpha-Fetoproteins
Transgenic Mice
Swine
T-Lymphocytes
Thymocytes
human AFP protein
Fetal Proteins
Thyroiditis
Phytohemagglutinins
Immunization

Keywords

  • α-Fetoprotein
  • Autoimmune thyroiditis
  • Immunoregulation
  • Thyroid peroxidase
  • Transgenic mouse

ASJC Scopus subject areas

  • Cancer Research

Cite this

Modulation of T cell function by alpha-fetoprotein : An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein. / Matsuura, Eiji; Kang, Y.; Kitakawa, H.; Ogata, A.; Kotani, T.; Ohtaki, S.; Nishi, Shinzo.

In: Tumor Biology, Vol. 20, No. 3, 05.1999, p. 162-171.

Research output: Contribution to journalArticle

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