Abstract
Experimental autoimmune thyroiditis was induced in transgenic mice (TG- 3) producing human α-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contrast, the development was significantly suppressed in TG-3 mice and mild histologic change was observed in only I out of 8 TG-3 mice (p <0.05). Serum anti-TPO antibody titers gradually increased in TG-3 mice as well as in control mice and there were no significant differences. In vitro phytohemagglutinin response of splenocytes from TG-3 mice was lower than that from control mice. Significantly reduced numbers of CD4+ and CD8+ splenocytes, total thymocytes, and CD4+ thymocytes were found in the nontreated TG-3 mice as compared with those in control mice. These results suggest that ubiquitously produced AFP modulates in vivo T cell development and/or T cell-dependent immune responses.
| Original language | English |
|---|---|
| Pages (from-to) | 162-171 |
| Number of pages | 10 |
| Journal | Tumor Biology |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1999 |
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Keywords
- α-Fetoprotein
- Autoimmune thyroiditis
- Immunoregulation
- Thyroid peroxidase
- Transgenic mouse
ASJC Scopus subject areas
- Cancer Research
Cite this
Modulation of T cell function by alpha-fetoprotein : An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein. / Matsuura, Eiji; Kang, Y.; Kitakawa, H.; Ogata, A.; Kotani, T.; Ohtaki, S.; Nishi, Shinzo.
In: Tumor Biology, Vol. 20, No. 3, 05.1999, p. 162-171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of T cell function by alpha-fetoprotein
T2 - An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein
AU - Matsuura, Eiji
AU - Kang, Y.
AU - Kitakawa, H.
AU - Ogata, A.
AU - Kotani, T.
AU - Ohtaki, S.
AU - Nishi, Shinzo
PY - 1999/5
Y1 - 1999/5
N2 - Experimental autoimmune thyroiditis was induced in transgenic mice (TG- 3) producing human α-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contrast, the development was significantly suppressed in TG-3 mice and mild histologic change was observed in only I out of 8 TG-3 mice (p <0.05). Serum anti-TPO antibody titers gradually increased in TG-3 mice as well as in control mice and there were no significant differences. In vitro phytohemagglutinin response of splenocytes from TG-3 mice was lower than that from control mice. Significantly reduced numbers of CD4+ and CD8+ splenocytes, total thymocytes, and CD4+ thymocytes were found in the nontreated TG-3 mice as compared with those in control mice. These results suggest that ubiquitously produced AFP modulates in vivo T cell development and/or T cell-dependent immune responses.
AB - Experimental autoimmune thyroiditis was induced in transgenic mice (TG- 3) producing human α-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contrast, the development was significantly suppressed in TG-3 mice and mild histologic change was observed in only I out of 8 TG-3 mice (p <0.05). Serum anti-TPO antibody titers gradually increased in TG-3 mice as well as in control mice and there were no significant differences. In vitro phytohemagglutinin response of splenocytes from TG-3 mice was lower than that from control mice. Significantly reduced numbers of CD4+ and CD8+ splenocytes, total thymocytes, and CD4+ thymocytes were found in the nontreated TG-3 mice as compared with those in control mice. These results suggest that ubiquitously produced AFP modulates in vivo T cell development and/or T cell-dependent immune responses.
KW - α-Fetoprotein
KW - Autoimmune thyroiditis
KW - Immunoregulation
KW - Thyroid peroxidase
KW - Transgenic mouse
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UR - http://www.scopus.com/inward/citedby.url?scp=0032923494&partnerID=8YFLogxK
U2 - 10.1159/000030059
DO - 10.1159/000030059
M3 - Article
VL - 20
SP - 162
EP - 171
JO - Tumor Biology
JF - Tumor Biology
SN - 1010-4283
IS - 3
ER -