Abstract
Hydroxyapatite materials are potentially useful for biomedical application, especially as vehicles for functional molecules. Structural control of bulk apatite materials, such as in the fabrication of hollow microspheres or porous structures, has been studied for this purpose. However, control of the internal structure of the source apatite crystal itself is still a challenge. Here, we show that small organic molecules incorporated in apatite crystals act as porogens which control the porous structure of apatite single crystal. The presence of amino acid under apatite synthesis conditions leads to firm bindings and encapsulation of the amino acid in apatite single crystals. Amino acid elimination by heating or electron beam irradiation enhances the pore formation in apatite single crystal. Moreover, incorporation of an acidic amino acid in apatite induces peapod like nanotubes in apatite single crystals. This study suggests the potential of using small organics for nano-structural control of apatite single crystals which would be valuable for enhancing drug loadings or modulating material digestion in vivo.
Original language | English |
---|---|
Pages (from-to) | 495-499 |
Number of pages | 5 |
Journal | Materials Chemistry and Physics |
Volume | 128 |
Issue number | 3 |
DOIs | |
Publication status | Published - Aug 15 2011 |
Externally published | Yes |
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Keywords
- Adsorption
- Biomaterials
- Inorganic compounds
- Nanostructures
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics
Cite this
Modulation of nanotube formation in apatite single crystal via organic molecule incorporation. / Matsumoto, Takuya; Uddin, Mohammad Hafiz; An, Sang Hyun; Arakawa, Kazuto; Taguchi, Eiji; Nakahira, Atsushi; Okazaki, Masayuki.
In: Materials Chemistry and Physics, Vol. 128, No. 3, 15.08.2011, p. 495-499.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of nanotube formation in apatite single crystal via organic molecule incorporation
AU - Matsumoto, Takuya
AU - Uddin, Mohammad Hafiz
AU - An, Sang Hyun
AU - Arakawa, Kazuto
AU - Taguchi, Eiji
AU - Nakahira, Atsushi
AU - Okazaki, Masayuki
PY - 2011/8/15
Y1 - 2011/8/15
N2 - Hydroxyapatite materials are potentially useful for biomedical application, especially as vehicles for functional molecules. Structural control of bulk apatite materials, such as in the fabrication of hollow microspheres or porous structures, has been studied for this purpose. However, control of the internal structure of the source apatite crystal itself is still a challenge. Here, we show that small organic molecules incorporated in apatite crystals act as porogens which control the porous structure of apatite single crystal. The presence of amino acid under apatite synthesis conditions leads to firm bindings and encapsulation of the amino acid in apatite single crystals. Amino acid elimination by heating or electron beam irradiation enhances the pore formation in apatite single crystal. Moreover, incorporation of an acidic amino acid in apatite induces peapod like nanotubes in apatite single crystals. This study suggests the potential of using small organics for nano-structural control of apatite single crystals which would be valuable for enhancing drug loadings or modulating material digestion in vivo.
AB - Hydroxyapatite materials are potentially useful for biomedical application, especially as vehicles for functional molecules. Structural control of bulk apatite materials, such as in the fabrication of hollow microspheres or porous structures, has been studied for this purpose. However, control of the internal structure of the source apatite crystal itself is still a challenge. Here, we show that small organic molecules incorporated in apatite crystals act as porogens which control the porous structure of apatite single crystal. The presence of amino acid under apatite synthesis conditions leads to firm bindings and encapsulation of the amino acid in apatite single crystals. Amino acid elimination by heating or electron beam irradiation enhances the pore formation in apatite single crystal. Moreover, incorporation of an acidic amino acid in apatite induces peapod like nanotubes in apatite single crystals. This study suggests the potential of using small organics for nano-structural control of apatite single crystals which would be valuable for enhancing drug loadings or modulating material digestion in vivo.
KW - Adsorption
KW - Biomaterials
KW - Inorganic compounds
KW - Nanostructures
UR - http://www.scopus.com/inward/record.url?scp=79957883085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79957883085&partnerID=8YFLogxK
U2 - 10.1016/j.matchemphys.2011.03.045
DO - 10.1016/j.matchemphys.2011.03.045
M3 - Article
AN - SCOPUS:79957883085
VL - 128
SP - 495
EP - 499
JO - Materials Chemistry and Physics
JF - Materials Chemistry and Physics
SN - 0254-0584
IS - 3
ER -