Modulation of nanotube formation in apatite single crystal via organic molecule incorporation

Takuya Matsumoto, Mohammad Hafiz Uddin, Sang Hyun An, Kazuto Arakawa, Eiji Taguchi, Atsushi Nakahira, Masayuki Okazaki

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Hydroxyapatite materials are potentially useful for biomedical application, especially as vehicles for functional molecules. Structural control of bulk apatite materials, such as in the fabrication of hollow microspheres or porous structures, has been studied for this purpose. However, control of the internal structure of the source apatite crystal itself is still a challenge. Here, we show that small organic molecules incorporated in apatite crystals act as porogens which control the porous structure of apatite single crystal. The presence of amino acid under apatite synthesis conditions leads to firm bindings and encapsulation of the amino acid in apatite single crystals. Amino acid elimination by heating or electron beam irradiation enhances the pore formation in apatite single crystal. Moreover, incorporation of an acidic amino acid in apatite induces peapod like nanotubes in apatite single crystals. This study suggests the potential of using small organics for nano-structural control of apatite single crystals which would be valuable for enhancing drug loadings or modulating material digestion in vivo.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalMaterials Chemistry and Physics
Volume128
Issue number3
DOIs
Publication statusPublished - Aug 15 2011
Externally publishedYes

Fingerprint

Apatites
Apatite
apatites
Nanotubes
nanotubes
Modulation
Single crystals
modulation
Molecules
single crystals
molecules
amino acids
Amino acids
Amino Acids
Acidic Amino Acids
Crystals
Durapatite
Microspheres
Hydroxyapatite
Encapsulation

Keywords

  • Adsorption
  • Biomaterials
  • Inorganic compounds
  • Nanostructures

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Modulation of nanotube formation in apatite single crystal via organic molecule incorporation. / Matsumoto, Takuya; Uddin, Mohammad Hafiz; An, Sang Hyun; Arakawa, Kazuto; Taguchi, Eiji; Nakahira, Atsushi; Okazaki, Masayuki.

In: Materials Chemistry and Physics, Vol. 128, No. 3, 15.08.2011, p. 495-499.

Research output: Contribution to journalArticle

Matsumoto, Takuya ; Uddin, Mohammad Hafiz ; An, Sang Hyun ; Arakawa, Kazuto ; Taguchi, Eiji ; Nakahira, Atsushi ; Okazaki, Masayuki. / Modulation of nanotube formation in apatite single crystal via organic molecule incorporation. In: Materials Chemistry and Physics. 2011 ; Vol. 128, No. 3. pp. 495-499.
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