Abstract
Background: Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a result of complex interactions between pituitary gonadotropins and autocrine and paracrine factors, including bone morphogenetic proteins (BMPs) that are expressed in the ovary. Methods: The effects of melatonin and BMPs on steroidogenesis were examined by using the primary cultures of rat granulosa cells. Main findings (Results): It was shown that melatonin has antagonistic effects on BMP-6 actions in the granulosa cells, suggesting that melatonin is likely to contribute to balancing the biological activity of endogenous BMPs that maintain progesterone production and luteinization in the growing follicles. Similar interactions between melatonin and BMP-smad signaling also were shown in the mechanism of controlling ovarian steroidogenesis by other ligands. Conclusion: A new role of melatonin in the regulation of endocrine homeostasis in relation to BMP activity is introduced in this review.
| Original language | English |
|---|---|
| Journal | Reproductive Medicine and Biology |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2018 |
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Keywords
- Bone morphogenetic protein
- Follicle-stimulating hormone
- Granulosa cells
- Melatonin
- Smad
- Steroidogenesis
ASJC Scopus subject areas
- Reproductive Medicine
- Cell Biology
Cite this
Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis. / Otsuka, Fumio.
In: Reproductive Medicine and Biology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis
AU - Otsuka, Fumio
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a result of complex interactions between pituitary gonadotropins and autocrine and paracrine factors, including bone morphogenetic proteins (BMPs) that are expressed in the ovary. Methods: The effects of melatonin and BMPs on steroidogenesis were examined by using the primary cultures of rat granulosa cells. Main findings (Results): It was shown that melatonin has antagonistic effects on BMP-6 actions in the granulosa cells, suggesting that melatonin is likely to contribute to balancing the biological activity of endogenous BMPs that maintain progesterone production and luteinization in the growing follicles. Similar interactions between melatonin and BMP-smad signaling also were shown in the mechanism of controlling ovarian steroidogenesis by other ligands. Conclusion: A new role of melatonin in the regulation of endocrine homeostasis in relation to BMP activity is introduced in this review.
AB - Background: Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a result of complex interactions between pituitary gonadotropins and autocrine and paracrine factors, including bone morphogenetic proteins (BMPs) that are expressed in the ovary. Methods: The effects of melatonin and BMPs on steroidogenesis were examined by using the primary cultures of rat granulosa cells. Main findings (Results): It was shown that melatonin has antagonistic effects on BMP-6 actions in the granulosa cells, suggesting that melatonin is likely to contribute to balancing the biological activity of endogenous BMPs that maintain progesterone production and luteinization in the growing follicles. Similar interactions between melatonin and BMP-smad signaling also were shown in the mechanism of controlling ovarian steroidogenesis by other ligands. Conclusion: A new role of melatonin in the regulation of endocrine homeostasis in relation to BMP activity is introduced in this review.
KW - Bone morphogenetic protein
KW - Follicle-stimulating hormone
KW - Granulosa cells
KW - Melatonin
KW - Smad
KW - Steroidogenesis
UR - http://www.scopus.com/inward/record.url?scp=85042544897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042544897&partnerID=8YFLogxK
U2 - 10.1002/rmb2.12089
DO - 10.1002/rmb2.12089
M3 - Article
JO - Reproductive Medicine and Biology
JF - Reproductive Medicine and Biology
SN - 1445-5781
ER -