Modulation by static magnetism of neuronal activity

Takao Hirai, Yasuaki Goto, Takeshi Takarada, Hideo Taniura, Yukio Yoneda

Research output: Contribution to journalReview article

Abstract

In neurons, the signal propagation involves both the conduction mediated by local electric currents through voltage-sensitive cation channels in axons and the transmission mediated by the exocytotic release of neurotransmitters from nerve endings into synaptic clefts. A great number of desperate efforts have been dedicated to biochemical, pharmacological and molecular biological studies on the elucidation of mechanisms underlying the neurotransmission at synapses, while relatively little attention has been paid to the comprehensive evaluation of the conduction except for local anesthetics. According to a physical theorem, exposure to magnetism should lead to the generation of a certain mechanical force in neurons with concomitant electric currents in a particular situation. In particular, repetitive transcranial magnetic stimulation is beneficial for the treatment of selected patients suffering from depression, bipolar affective disorder and schizophrenia as a possible alternative to the electroconvulsive therapy for refractory depression. In this review, therefore, we will summarize our recent advances made on the neurochemical and molecular biological elucidation in cultured rat hippocampal neurons toward better understanding by the readers of different disciplines of mechanisms associated with the modulation by magnetism of the neuronal activity in the brain.

Original languageEnglish
Pages (from-to)21-35
Number of pages15
JournalBiomedical Reviews
Volume15
Issue number1
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Magnetism
Neurons
Modulation
Electric currents
Treatment-Resistant Depressive Disorder
Electroconvulsive Therapy
Nerve Endings
Transcranial Magnetic Stimulation
Local Anesthetics
Mood Disorders
Bipolar Disorder
Synaptic Transmission
Refractory materials
Synapses
Neurotransmitter Agents
Axons
Cations
Rats
Brain
Schizophrenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hirai, T., Goto, Y., Takarada, T., Taniura, H., & Yoneda, Y. (2004). Modulation by static magnetism of neuronal activity. Biomedical Reviews, 15(1), 21-35.

Modulation by static magnetism of neuronal activity. / Hirai, Takao; Goto, Yasuaki; Takarada, Takeshi; Taniura, Hideo; Yoneda, Yukio.

In: Biomedical Reviews, Vol. 15, No. 1, 2004, p. 21-35.

Research output: Contribution to journalReview article

Hirai, T, Goto, Y, Takarada, T, Taniura, H & Yoneda, Y 2004, 'Modulation by static magnetism of neuronal activity', Biomedical Reviews, vol. 15, no. 1, pp. 21-35.
Hirai T, Goto Y, Takarada T, Taniura H, Yoneda Y. Modulation by static magnetism of neuronal activity. Biomedical Reviews. 2004;15(1):21-35.
Hirai, Takao ; Goto, Yasuaki ; Takarada, Takeshi ; Taniura, Hideo ; Yoneda, Yukio. / Modulation by static magnetism of neuronal activity. In: Biomedical Reviews. 2004 ; Vol. 15, No. 1. pp. 21-35.
@article{a4b2ac487ca044f3b54bd3ec89a717ea,
title = "Modulation by static magnetism of neuronal activity",
abstract = "In neurons, the signal propagation involves both the conduction mediated by local electric currents through voltage-sensitive cation channels in axons and the transmission mediated by the exocytotic release of neurotransmitters from nerve endings into synaptic clefts. A great number of desperate efforts have been dedicated to biochemical, pharmacological and molecular biological studies on the elucidation of mechanisms underlying the neurotransmission at synapses, while relatively little attention has been paid to the comprehensive evaluation of the conduction except for local anesthetics. According to a physical theorem, exposure to magnetism should lead to the generation of a certain mechanical force in neurons with concomitant electric currents in a particular situation. In particular, repetitive transcranial magnetic stimulation is beneficial for the treatment of selected patients suffering from depression, bipolar affective disorder and schizophrenia as a possible alternative to the electroconvulsive therapy for refractory depression. In this review, therefore, we will summarize our recent advances made on the neurochemical and molecular biological elucidation in cultured rat hippocampal neurons toward better understanding by the readers of different disciplines of mechanisms associated with the modulation by magnetism of the neuronal activity in the brain.",
author = "Takao Hirai and Yasuaki Goto and Takeshi Takarada and Hideo Taniura and Yukio Yoneda",
year = "2004",
language = "English",
volume = "15",
pages = "21--35",
journal = "Biomedical Reviews",
issn = "1310-392X",
publisher = "Bulgarian-American Center",
number = "1",

}

TY - JOUR

T1 - Modulation by static magnetism of neuronal activity

AU - Hirai, Takao

AU - Goto, Yasuaki

AU - Takarada, Takeshi

AU - Taniura, Hideo

AU - Yoneda, Yukio

PY - 2004

Y1 - 2004

N2 - In neurons, the signal propagation involves both the conduction mediated by local electric currents through voltage-sensitive cation channels in axons and the transmission mediated by the exocytotic release of neurotransmitters from nerve endings into synaptic clefts. A great number of desperate efforts have been dedicated to biochemical, pharmacological and molecular biological studies on the elucidation of mechanisms underlying the neurotransmission at synapses, while relatively little attention has been paid to the comprehensive evaluation of the conduction except for local anesthetics. According to a physical theorem, exposure to magnetism should lead to the generation of a certain mechanical force in neurons with concomitant electric currents in a particular situation. In particular, repetitive transcranial magnetic stimulation is beneficial for the treatment of selected patients suffering from depression, bipolar affective disorder and schizophrenia as a possible alternative to the electroconvulsive therapy for refractory depression. In this review, therefore, we will summarize our recent advances made on the neurochemical and molecular biological elucidation in cultured rat hippocampal neurons toward better understanding by the readers of different disciplines of mechanisms associated with the modulation by magnetism of the neuronal activity in the brain.

AB - In neurons, the signal propagation involves both the conduction mediated by local electric currents through voltage-sensitive cation channels in axons and the transmission mediated by the exocytotic release of neurotransmitters from nerve endings into synaptic clefts. A great number of desperate efforts have been dedicated to biochemical, pharmacological and molecular biological studies on the elucidation of mechanisms underlying the neurotransmission at synapses, while relatively little attention has been paid to the comprehensive evaluation of the conduction except for local anesthetics. According to a physical theorem, exposure to magnetism should lead to the generation of a certain mechanical force in neurons with concomitant electric currents in a particular situation. In particular, repetitive transcranial magnetic stimulation is beneficial for the treatment of selected patients suffering from depression, bipolar affective disorder and schizophrenia as a possible alternative to the electroconvulsive therapy for refractory depression. In this review, therefore, we will summarize our recent advances made on the neurochemical and molecular biological elucidation in cultured rat hippocampal neurons toward better understanding by the readers of different disciplines of mechanisms associated with the modulation by magnetism of the neuronal activity in the brain.

UR - http://www.scopus.com/inward/record.url?scp=77952439563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952439563&partnerID=8YFLogxK

M3 - Review article

VL - 15

SP - 21

EP - 35

JO - Biomedical Reviews

JF - Biomedical Reviews

SN - 1310-392X

IS - 1

ER -